Results 271 to 280 of about 198,219 (355)

Listening to Hong Kong children's perspectives through pretend play

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley   +1 more source

Structural insights into modular polyketide synthases: From individual domains to supramolecular assemblies

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Recent structural advances have enabled modeling of polyketide synthases reaction cycles and revealed key determinants of directionality and specificity in modular PKSs. This review introduces structural features of PKS domains and their organization within the PKS modules.
Minjae Kim   +2 more
wiley   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

open access: yesBMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang   +7 more
wiley   +1 more source

A Proposed Circular Economy Readiness Framework for the Rail Sector, A Literature Review and Conceptual Framework

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The circular economy (CE) offers a transformative approach to addressing global sustainability challenges, yet few frameworks integrate it with business strategy, systems thinking (ST) and asset management (AM), especially within critical infrastructure sectors like rail. This paper conducts a comprehensive literature review to assess existing
Carl Waring, Kapila Liyanage
wiley   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

open access: yesCancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou   +6 more
wiley   +1 more source

Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects. [PDF]

open access: yesArthrosc Tech
Franco D   +5 more
europepmc   +1 more source

Deserts, Rivers, Pools, and Billabongs: Water Features of the Nitrogenase Proteins, and their Functions

open access: yesChemBioChem, EarlyView.
In the protein surrounding the active site of nitrogenase there is a large anhydrous desert, traversed by two watercourses necessary for the enzyme to convert N2 to NH3. Various pools exist, but their water seems to be stagnant. This review examines the occurrence and function of water inside the protein that contains the catalytic site of the enzyme ...
Ian Dance
wiley   +1 more source

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