Results 131 to 140 of about 63,291,506 (350)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A solid-state digital temperature recorder for space use [PDF]

A solid-state, digital, temperature recorder has been developed for use in space experiments. The recorder is completely self-contained and includes a temperature sensor; all necessary electronics for signal conditioning, processing, storing, control and
Bennett, L. D., Deboo, G. J., Steinhaver, R. A., Westbrook, R. M.   +3 more
core   +1 more source

Space station models, mockups and simulators [PDF]

, 1985
Schematic outlines for space station models, mockups, and simulators are presented. The types of Boeing models, mockups, and simulators are given along with the classes and characteristics.
Miller, K. H., Osgood, A.
core   +1 more source

Jump Markov models and transition state theory: the Quasi-Stationary Distribution approach

, 2016
We are interested in the connection between a metastable continuous state space Markov process (satisfying e.g. the Langevin or overdamped Langevin equation) and a jump Markov process in a discrete state space.
Di Gesù, Giacomo, Lelièvre, Tony, Nectoux, Boris, Peutrec, Dorian Le   +3 more
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

ESA activities in space laser sounding and ranging [PDF]

, 1986
Laser remote sensing from space is undoubtedly one of the most promising means to obtain essential atmospheric and geophysical parameters on a global scale.
Lutz, H.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Space Use and Habitat Selection by Resident and Transient Red Wolves (Canis rufus)

PLoS ONE, 2016
Recovery of large carnivores remains a challenge because complex spatial dynamics that facilitate population persistence are poorly understood. In particular, recovery of the critically endangered red wolf (Canis rufus) has been challenging because of ...
Joseph W. Hinton, C. Proctor, M. Kelly, Frank T. van Manen, M. Vaughan, Michael J. Chamberlain   +5 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Decoding Owl Calls: Refining Occupancy Inference From Passive Acoustic Monitoring

Ecology and Evolution
Many territorial species use vocalizations as a primary form of territory defense, and the areas actively defended do not necessarily correspond with an individual's home range.
Natalie M. Rugg, Cara L. Appel, Julianna M. A. Jenkins, Chris McCafferty, Taal Levi, Damon B. Lesmeister   +5 more
doaj   +1 more source