Results 41 to 50 of about 2,463,232 (269)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Analyses, Modeling, and SVPWM Control of a Three-Level T-NPC Inverter to Reduce Common-Mode Voltage Under Open-Circuit Fault in a Neutral-Point Switch

IEEE Access
This paper proposes a new space vector pulse-width modulation technique for reducing the common-mode voltage (SVPWM2) in a three-level T-type neutral-point-clamped voltage source inverter working under switch-open-circuit fault on a neutral-point ...
Hong-Phong Nguyen Le, Khoa Dang Pham, Nho-van Nguyen   +2 more
doaj   +1 more source

Asymmetrical Six-Phase Space Vector Pwm Scheme

Mokslas: Lietuvos Ateitis, 2014
Multiphase electric motors have smaller torque pulsations and are more reliable that their three-phase alternatives. However, standard electricity grids around the world are three-phase, so power inverter is needed to drive multiphase motors. Inverter is
Tadas Lipinskis
doaj   +1 more source

New Vector-Space Embeddings for Recommender Systems

Applied Sciences, 2021
In this work, we propose a novel recommender system model based on a technology commonly used in natural language processing called word vector embedding.
Sandra Rizkallah, Amir F. Atiya, Samir Shaheen   +2 more
doaj   +1 more source

On computation of the first Baues--Wirsching cohomology of a freely-generated small category

, 2014
The Baues--Wirsching cohomology is one of the cohomologies of a small category. Our aim is to describe the first Baues--Wirsching cohomology of the small category generated by a finite quiver freely.
B. Mitchell, E.L. Green, H.J. Baues, R.-O. Buchweitz, Y. Han   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Generalized Runge-Lenz Vector in Taub-Nut Spinning Space

, 1994
The generalized Killing equations and the symmetries of Taub-NUT spinning space are investigated. For spinless particles the Runge-Lenz vector defines a constant of motion directly, whereas for spinning particles it now requires a non-trivial ...
Atiyah, Barducci, Berezin, Brink, Brink, Carter, Carter, Casalbuoni, Chandrasekhar, Chandrasekhar, Cordani, Dietz, Floyd, Gibbons, Gibbons, Gibbons, Gibbons, Gross, Hawking, Manton, Manton, Manton, Mihai Visinescu, Misner, Penrose, Rietdijk, Rietdijk, Sorkin, van Holten, Visinescu, Visinescu, Yano   +31 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Generalized space vector controls for MLZSI

Ain Shams Engineering Journal, 2015
This paper proposes two advanced algorithms for multilevel Z-source inverter (MLZSI), which employ space vector control (SVC) as control algorithm of cascaded H-bridge multilevel Z-source inverter; where output voltage is achieved by summing the output ...
Aida Baghbany Oskouei, Ali Reza Dehghanzadeh   +1 more
doaj   +1 more source