Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Advanced Materials, EarlyView.Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Thermal Control Design of the ESCAPADE Mars Space Vehicles [PDF]
Sean Reilly, Rocket Lab USA, USADaniel Arevalo-Londona, Rocket Lab USA, USASteven Huang, Rocket Lab USA, USATaylor Vincent, Rocket Lab USA, USAKarl Scherf, Rocket Lab USA, USATerry Muy, Rocket Lab USA, USAVincent Tarantini, Rocket Lab USA, USAJuan Cepeda-
Arevalo-Londona, Daniel +7 more
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Images from High-Energy Astrophysics Missions [PDF]
This collection of images features spacecraft and instruments used for high-energy research, typically studies of X-rays and Gamma rays. The collection includes pictures of early astronomy rockets and instruments, an archive of videos, and a large ...
core +2 more sources
Topology‐Orchestrated Multi‐physical Energy Control in Turtle Shell‐Inspired Metamaterials
Advanced Materials, EarlyView.A turtle shell‐inspired lattice metamaterial efficiently manages acoustic, fluid‐thermal, and mechanical energy flows simultaneously. The unique hybrid‐coupling architecture achieves superior sound attenuation via pore‐cavity resonance, facilitates effective airflow transport, and maximizes mechanical energy absorption through multistage cell ...
Xi Wang +3 more
wiley +1 more source
Human Factors Considerations for Space Traffic Displays in the Cockpit [PDF]
, 2015 The commercial spaceflight era is ushering in a number of suborbital and orbital space vehicles that exceed the standard vertical dimensions (i.e., between 0 and 60,000 ft.) of the current air traffic management system.
Dattel, Andrew R, Thropp, Jennifer E
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Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review
Advanced Materials, EarlyView.Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase +6 more
wiley +1 more source
Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation
Advanced Materials, EarlyView.LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines +10 more
wiley +1 more source
Conception and development of an adaptive optics testbed for free-space optical communication [PDF]
, 2009 Optical free space communications are an efficient approach to transmit high data-rates with small antennas and low power consumption over large distances. Possible scenarios are links between satellites, up- and down-links from and to ground stations as
Moll, Florian
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Escaping the Scaling Relationships in Oxygen Reduction Catalysis: Implications for PEM Fuel Cells
Advanced Materials, EarlyView.Escaping the scaling relationships of the oxygen reduction reaction is vital for hydrogen fuel cells. This outlook examines how interfacial heterogeneity, spanning the subsurface lattice, chemisorption layer, and near‐interface solvation volume, mechanistically decouples intermediate binding energetics.
Muhammad Bilal Wazir +2 more
wiley +1 more source
The Profile Envision and Splice Tool (PRESTO): Developing an Atmospheric Wind Analysis Tool for Space Launch Vehicles Using Python [PDF]
, 2017 Tropospheric winds are an important driver of the design and operation of space launch vehicles. Multiple types of weather balloons and Doppler Radar Wind Profiler (DRWP) systems exist at NASA's Kennedy Space Center (KSC), co-located on the United States
Orcutt, John M. +3 more
core +1 more source