Results 91 to 100 of about 65,472 (268)

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Space debris contributions to night sky brightness

Astronomy & Astrophysics
Aims. We quantify the uncertainty in space debris contributions to night sky brightness by comparing predictions from two major debris environment models and assessing the resulting signal-to-noise degradation for ground-based astronomical observations ...
Wallner S., Kocifaj M., Silha J.
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Multistatic Localisation in Passive Radar System for LEO Space Objects Observation Using Terrestrial Illuminators and LOFAR Radio Telescope

IET Radar, Sonar & Navigation
The paper introduces and discusses the concept and findings of experimental trials focused on the passive multistatic radar localisation of low‐Earth orbit (LEO) space objects using terrestrial illuminators and a LOFAR (LOw‐Frequency ARray) radio ...
Konrad Jędrzejewski, Mateusz Malanowski, Marek Płotka, Krzysztof Kulpa, Mariusz Pożoga   +4 more
doaj   +1 more source

Euclid

Astronomy & Astrophysics
Context. The performance of the Euclid system is defined in terms of image quality metrics tuned to the weak gravitational lensing cosmological probe.
Anselmi A., Laureijs R., Racca G. D., Costa G., Courcould Mifsud L., Cuillandre J.-C., Gottero M., Hoekstra H., Kuijken K., Mareschi V., Miller L., Mottini S., Stramaccioni D., Altieri B., Amara A., Andreon S., Auricchio N., Baccigalupi C., Baldi M., Balestra A., Bardelli S., Bender R., Biviano A., Branchini E., Brescia M., Camera S., Cañas-Herrera G., Capobianco V., Carbone C., Carretero J., Castellano M., Castignani G., Cavuoti S., Cimatti A., Colodro-Conde C., Congedo G., Conselice C. J., Conversi L., Copin Y., Courbin F., Courtois H. M., Cropper M., Da Silva A., Degaudenzi H., De Lucia G., Dole H., Dubath F., Ducret F., Duncan C. A. J., Dupac X., Dusini S., Escoffier S., Fabricius M., Farina M., Farinelli R., Faustini F., Ferriol S., Finelli F., Fourmanoit N., Frailis M., Franceschi E., Fumana M., Galeotta S., George K., Gillis B., Giocoli C., Gracia-Carpio J., Grazian A., Grupp F., Haugan S. V. H., Hoar J., Holmes W., Hormuth F., Hornstrup A., Jahnke K., Jhabvala M., Keihänen E., Kermiche S., Kiessling A., Kohley R., Kubik B., Kunz M., Kurki-Suonio H., Le Brun A. M. C., Ligori S., Lilje P. B., Lindholm V., Lloro I., Mainetti G., Maino D., Maiorano E., Mansutti O., Marggraf O., Martinelli M., Martinet N., Marulli F., Massey R. J., Medinaceli E., Mei S., Mellier Y., Meneghetti M., Merlin E., Meylan G., Mora A., Moresco M., Moscardini L., Nakajima R., Neissner C., Nichol R. C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Percival W. J., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Raison F., Rebolo R., Renzi A., Rhodes J., Riccio G., Romelli E., Roncarelli M., Rosset C., Rossetti E., Saglia R., Sakr Z., Salvignol J.-C., Sánchez A. G., Sapone D., Sartoris B., Schirmer M., Schneider P., Schrabback T., Secroun A., Seidel G., Serrano S., Sirignano C., Sirri G., Skottfelt J., Stanco L., Steinwagner J., Tallada-Crespí P., Tavagnacco D., Taylor A. N., Teplitz H. I., Tereno I., Tessore N., Toft S., Toledo-Moreo R., Torradeflot F., Tutusaus I., Valentijn E. A., Valenziano L., Valiviita J., Vassallo T., Verdoes Kleijn G., Veropalumbo A., Wang Y., Weller J., Zacchei A., Zamorani G., Zucca E., Ballardini M., Bolzonella M., Bozzo E., Burigana C., Cabanac R., Cappi A., Escartin Vigo J. A., Gabarra L., Hartley W. G., Martín-Fleitas J., Matthew S., Mauri N., Metcalf R. B., Pezzotta A., Pöntinen M., Risso I., Scottez V., Sereno M., Tenti M., Viel M., Wiesmann M., Akrami Y., Andika I. T., Anselmi S., Archidiacono M., Atrio-Barandela F., Bertacca D., Bethermin M., Blanchard A., Blot L., Bonici M., Borgani S., Brown M. L., Bruton S., Calabro A., Camacho Quevedo B., Caro F., Carvalho C. S., Castro T., Cogato F., Conseil S., Cooray A. R., Cucciati O., Davini S., Desprez G., Díaz-Sánchez A., Diaz J. J., Di Domizio S., Diego J. M., Elkhashab M. Y., Enia A., Fang Y., Ferrari A. G., Finoguenov A., Franco A., Ganga K., García-Bellido J., Gasparetto T., Gaztanaga E., Giacomini F., Gianotti F., Gozaliasl G., Guidi M., Gutierrez C. M., Hall A., Hildebrandt H., Hjorth J., Kajava J. J. E., Kang Y., Kansal V., Karagiannis D., Kiiveri K., Kim J., Kirkpatrick C. C., Kruk S., Le Graet J., Legrand L., Lembo M., Lepori F., Leroy G., Lesci G. F., Lesgourgues J., Leuzzi L., Liaudat T. I., Liu S. J., Loureiro A., Macias-Perez J., Magliocchetti M., Mannucci F., Maoli R., Martins C. J. A. P., Maurin L., Miluzio M., Monaco P., Montoro A., Moretti C., Morgante G., Nadathur S., Naidoo K., Navarro-Alsina A., Nesseris S., Paoletti D., Passalacqua F., Paterson K., Patrizii L., Pisani A., Potter D., Quai S., Radovich M., Sacquegna S., Sahlén M., Sanders D. B., Sarpa E., Schneider A., Sciotti D., Sellentin E., Smith L. C., Tanidis K., Testera G., Teyssier R., Tosi S., Troja A., Tucci M., Valieri C., Venhola A., Vergani D., Verza G., Vielzeuf P., Walton N. A.   +295 more
doaj   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source