Results 131 to 140 of about 7,041 (240)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, Volume 16, Issue 8, Page 1501-1508, August 2026.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis. [PDF]

J Cachexia Sarcopenia Muscle
Padilha CS, Figueiredo C, Deminice R, Ribeiro AS, Newton RU, Hart NH, Rosa-Neto JC, Seelaender M, Lira FS.   +8 more
europepmc   +1 more source

Life on Mars? The physiological perspective

Experimental Physiology, EarlyView.
Ronan M. G. Berg, Damian M. Bailey
wiley   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Asymmetric Optic Disc Edema in Astronauts: A Narrative Review Proposing an Interplay Between Ocular Venous Congestion and Glymphatic Transport. [PDF]

Life (Basel)
Wostyn P, Nedergaard M, Gibson CR, Mader TH.   +3 more
europepmc   +1 more source

Understanding Oral Hygiene and Periodontal Health in Space Using a Bedrest Analog Model for Weightlessness (NASA Sensorimotor Countermeasures Study)

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Aims To investigate longitudinal alterations in oral hygiene, gingival inflammation, and salivary secretion during a 60‐day head‐down tilt bed rest (HDTBR) protocol as a validated ground‐based analog of microgravity. Materials and Methods Twenty‐four healthy volunteers participated in a 60‐day, 6° HDTBR study conducted under strictly ...
Sonja Henny Maria Derman, Laura de Boni, Edwin Mulder, Stefan Möstl, Julia Jagel, Teresa Kruse, Anna Greta Barbe   +6 more
wiley   +1 more source

Anterior segment biomechanics and intraocular pressure in microgravity: implications for future spaceflight studies. [PDF]

NPJ Microgravity
Weaver A, Ong J, Sandhur BS, Sampige R, Black A, Lee AG, Berdahl J, Gibson CR, Mader TH.   +8 more
europepmc   +1 more source

Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Spaceflight induces altered physiology that has the potential to alter medication pharmacokinetics due to factors including gastrointestinal motility, fluid balance, circulatory dynamics, hormonal changes, and metabolic alterations. Here, we report the first pharmacokinetic analysis using blood samples during spaceflight.
David Mampre, Robert Guttendorf, Jennifer Zimmer, Brooke Whitson, James Huggins, Chad Christianson, Erik Burns, Nicolas Heft, Marissa Rosenberg, Amran Asadi, Jaime Mateus, James Rudge, Takako Mizuno, John Donehoo   +13 more
wiley   +1 more source

Microgravity as a translational model for metabolic dysfunction: implications for obesity, insulin resistance, steatotic liver and pancreatic diseases. [PDF]

Front Endocrinol (Lausanne)
Vadukoot Lazar M, C S Menon A, Gopalakrishna R.   +2 more
europepmc   +1 more source

Beyond intracranial pressure: Cerebrospinal fluid compartmentalization in spaceflight‐associated neuro‐ocular syndrome

Experimental Physiology, EarlyView.
Susan P. Mollan, Damian M. Bailey
wiley   +1 more source