Results 191 to 200 of about 777,065 (243)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

open access: yesAdvanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang   +12 more
wiley   +1 more source

Adapting upright light sheet fluorescence microscopy for imaging at air-liquid interface. [PDF]

open access: yesNpj Imaging
Hobson CM   +18 more
europepmc   +1 more source

Accelerated Materials Discovery Through In Situ X‐ray Diffraction: Solvothermal Formation of PdxMy (M═Si, Ge, Sn, Pb) Intermetallic Nanoparticles

open access: yesAdvanced Materials, EarlyView.
In situ PXRD data on solvothermal reactions accelerate materials discovery while simultaneously providing fundamental insights into complex crystal formation processes. Using PdxMy (M = Si, Ge, Sn, Pb) as an example, a general formation mechanism is identified, and specific synthesis strategies for ex situ preparation of SnPd2, Sn13Pd20, and SnPd ...
Anders Bæk Borup   +1 more
wiley   +1 more source

Descriptor‐Informed Screening of Interface‐Active Molecules for Efficient Magnesium Metal Anodes

open access: yesAdvanced Materials, EarlyView.
A descriptor‐informed molecular screening strategy identifies 4‐bromo‐N, N‐dimethylaniline (BrNNA) as an interface‐active electrolyte component that enables fast Mg stripping/plating in Mg(TFSI)2‐based electrolytes. By simultaneously regulating Mg2+ solvation and interphase formation, the BrNNA‐containing electrolyte delivers activation‐free Mg ...
Hao Xu   +16 more
wiley   +1 more source

A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems. [PDF]

open access: yesEMBO J
Migur A   +8 more
europepmc   +1 more source

Highly Sensitive Broadband Photodetectors Based on Donor–Acceptor 2D Conjugated Coordination Polymers

open access: yesAdvanced Materials, EarlyView.
Donor–acceptor molecular design and chemical vapor deposition growth enable the two‐dimensional nickel‐tetraaminobenzoquinone films with strong broadband absorption and efficient charge separation. The resulting photodetectors exhibit a structured broadband response with a high responsivity of ∼3.1 A W−1 and a response time of ∼170 µs, which surpasses ...
Yunxu Chen   +14 more
wiley   +1 more source

CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif. [PDF]

open access: yesNucleic Acids Res
Chilamkurthy R   +13 more
europepmc   +1 more source

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