Results 41 to 50 of about 1,630,376 (260)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Hirak : un mouvement socio-politique inédit et inventif. Temps suspendu et/ou en devenir
إنسانيات, 2020 The article is an exploration, in the short and medium term, of the history of political and social struggles in 20th century Algeria. It is an obligatory and a necessary investigation in order to better apprehend the complexity of the hirak of February ...
Omar Carlier
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La Tour de Doan Bui. Une architex-Tour perecquienne ?
Revue Italienne d'Etudes FrançaisesAfter the publication of Le Silence de mon père in 2016, Doan Bui released her first novel, La Tour ou un chien à Chinatown, in 2022. The novel portrays the lives of the inhabitants of a tower, the Tour Melbourne, located in Paris’s 13th arrondissement ...
Francesca Pozzetti
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استفاده ترکیبی از چند روش در امکان سنجی قابلیت پیاده مداری معابر شهری [PDF]
معماری و شهرسازی ایران, 2019 پیاده مداری اهمیتی اساسی در ادراک هویت فضایی و دریافت کیفیت محیط دارد و به این لحاظ مورد توجه نظریه پردازان متعددی قرار گرفته است. با توجه به تلاش های اخیر برنامه ریزان و طراحان جهت تشویق مردم به پیاده روی، مدل ها و روش های بسیاری جهت امکان سنجی پیاده ...
پویان شهابیان
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
On the W@terfront, 2015 The main element which justifies any urban generation or re-generation process is collective housing. Also it is the element which connects the other components of the city: public equipments, urban space, infrastructures...
Jaume Asensi
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