Advanced Science, EarlyView.Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová +27 more
wiley +1 more source
Correction: Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans. [PDF]
DiabetologiaWreven E +23 more
europepmc +1 more source
Actionable Forecasting as a Determinant of Biological Adaptation
Advanced Science, EarlyView.A new framework reveals how biological systems can achieve precise adaptation by tracking an actionable target that combines the current optimal state with its rate of change. This approach, implemented through dynamics‐informed neural networks, demonstrates that predictive mechanisms like circadian rhythms become beneficial when environmental sensing ...
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Correction: Second-Line Treatment Options for Patients with Metastatic Triple-Negative Breast Cancer: A Review of the Clinical Evidence. [PDF]
Target OncolGarcía-Saenz JÁ +5 more
europepmc +1 more source
A Fresh Perspective on the Continuing Problem of Housing Segregation and Move-In Violence: A review of Hate Thy Neighbor by Jeannine Bell [PDF]
, 2014 Spain, Julie
core +1 more source
Advanced Science, EarlyView.Piezoelectric microdevices, composed of ZnO nanosheets acting as nanogenerators and grown on silicon microparticles, are designed and fabricated to deliver precise electrical cell stimulation. This study optimizes nanosheet growth and microparticle size to enhance electrical cell activation performance while minimizing cellular internalization.
Laura Lefaix +4 more
wiley +1 more source
Effects of depression on patients suffering from ankylosing spondylitis: a comparative study. [PDF]
Sao Paulo Med JCortés-Rodríguez A +7 more
europepmc +1 more source
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
Advanced Science, EarlyView.This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong +17 more
wiley +1 more source
Successful desensitization protocol to alglucosidase and avalglucosidase alfa in a patient with infantile-onset Pompe disease. [PDF]
Mol Genet Metab RepGendive M +6 more
europepmc +1 more source