Results 191 to 200 of about 2,720,872 (300)

Flux Science Without Borders: Strengthening Ecosystem Flux Capacity in Latin America. [PDF]

Glob Chang Biol
Tarin T, Alvarado-Barrientos MS, Del Castillo EG, Cervantes-Jiménez M, Sánchez-Mejía Z, Cueva A, Delgado-Guerrero A, Flores-Renteria D, Garatuza-Payan J, Hinojo-Hinojo C, Meza K, Moore DJP, Pérez-Ruiz ER, Restrepo-Acevedo AM, Restrepo-Coupe N, Revenga JC, Tonti NE, Roman DT, González MA, Uuh-Sonda JM, Vargas R, Vargas-Terminel ML, Velasco E, Villarreal S, Biraud SC, Torn MS, Yepez EA.   +26 more
europepmc   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Patient perspectives on delays in care for kidney stones: A qualitative analysis. [PDF]

PLoS One
Ibrahim II, Zager DL, Charondo LB, Zamudio-Haas S, Ackerman SL, Bayne DB.   +5 more
europepmc   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

A step toward inclusion: A transparent dataset for automatic text simplification for screen reader users. [PDF]

Data Brief
Pérez-Rojas N, Solís M, Calderón-Ramírez S, Arias-Monge M, Saggion H, Xie-Li D.   +5 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Correction for Sabzehei et al., Exploring PrP^C unfolding as a critical step preceding its refolding in the context of PrP^Sc propagation. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Caregiver-Implemented Early Language Interventions for Latine Children With Language Delays: A Systematic Review. [PDF]

Am J Speech Lang Pathol
López González AC, Garcia N, Gross MC, Andrianopoulos M.   +3 more
europepmc   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Impact of the Food4Moms produce prescription program on readiness for healthy eating, fruit and vegetable intake, and food security. [PDF]

PLoS One
Segura-Pérez S, Gionteris K, Hromi-Fiedler A, O'Connor Duffany K, Rhodes EC, Rodonis S, Aleaga-Figueroa A, Galdamez G, Tristán Urrutia A, Pérez-Escamilla R.   +9 more
europepmc   +1 more source