Results 41 to 50 of about 2,758,728 (278)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

FRANCISCO FERNÁNDEZ SEGADO (ed.): The Spanish Constitution in the European Constitutional Context

open access: yesAnuario Iberoamericano de Justicia Constitucional, 2016
BIBLIOGRÁFICOSde Costa Rica y en la jurisprudencia de su Sala Constitucional (Mora Mora).6. Podemos concluir esta recensión recomendando la lectura de este libro a todos los interesados por el constitucionalismo iberoamericano y, en especial, por la ...
Joaquín Brage Camazano
semanticscholar  

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Taking the Spanish government before the law [PDF]

open access: yes, 2017
I lay out the procedure and the logic for suing the Spanish government for its treatment of the Catalan referendum of 1 October 2017. I claim that the Spanish Constitutional Tribunal's decisions which gave legal ground for Mariano Rajoy's attempt to ...
Azmanova, Albena
core  

Surface modification of 3D‐printed polycaprolactone scaffolds with silk fibroin for bone tissue engineering

open access: yesFEBS Open Bio, EarlyView.
Coating 3D‐printed PCL scaffolds with silk fibroin can improve biocompatibility and bone cell adhesion. One innovative design for tissue‐engineering scaffolds uses 3D printing technology. Here, we used polycaprolactone (PCL) filament as a biocompatible material to design a porous 3D scaffold for bone tissue engineering.
Hamed Koeini   +7 more
wiley   +1 more source

Dictionary of Spanish Language 22 ed. (2001) - DLE22 (ELEXIS)

open access: yes, 2020
Diccionario de la lengua española 22 ed. (2001). The Diccionario de la lengua española is the standard dictionary of Spanish (a.k.a. Castilian) edited and produced by the Royal Spanish Academy (RAE). Its first edition dates from 1780, and its latest one
Royal Spanish Academy
core   +1 more source

The review of article 145 CE in a federal reform of the Spanish Constitution

open access: yesRevista de Derecho Político, 2018
: In the current context of serious crisis of the territorial pattern envisaged by the 1978 Spanish Constitution, many authors have advocated for a reform of the State of the Autonomies in federal terms, either for transforming it fully into a Federal ...
Ignacio González García
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Family Constitution and Business Performance: Moderating Factors

open access: yes, 2017
This study analyzes the relationship between implementing a Family Constitution (Protocol) and future family business performance. We analyze a unique sample of 530 Spanish family businesses. Half of these firms received financial aid from the government
Rocio Arteaga, Susana Menéndez-Requejo
semanticscholar   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes   +75 more
wiley   +1 more source

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