Results 41 to 50 of about 81,428 (311)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, Accepted Article.
Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo   +19 more
wiley   +1 more source

Efficient Computation of Expectations under Spanning Tree Distributions

open access: yesTransactions of the Association for Computational Linguistics, 2021
We give a general framework for inference in spanning tree models. We propose unified algorithms for the important cases of first-order expectations and second-order expectations in edge-factored, non-projective spanning-tree models.
Ran Zmigrod, Tim Vieira, Ryan Cotterell
doaj   +1 more source

Hybrid Auxetic Architectures: Integrating Curvature‐Driven Design for Enhanced Mechanical Tunability and Structural Performance

open access: yesAdvanced Engineering Materials, EarlyView.
Curvature‐tuned auxetic lattices are designed, fabricated, and mechanically characterized to reveal how geometric curvature governs stretchability, stress redistribution, and Poisson's ratio evolution. Photoelastic experiments visualize stress pathways, while hyperelastic simulations quantify deformation mechanics.
Shuvodeep De   +3 more
wiley   +1 more source

Efficient and Effective Directed Minimum Spanning Tree Queries

open access: yesMathematics, 2023
Computing directed Minimum Spanning Tree (DMST) is a fundamental problem in graph theory. It is applied in a wide spectrum of fields from computer network and communication protocol design to revenue maximization in social networks and syntactic parsing ...
Zhuoran Wang   +4 more
doaj   +1 more source

Engineering Deformation and Failure in Diamond Triply Periodic Minimal Surface Lattices via 3D Wall‐Thickness Grading

open access: yesAdvanced Engineering Materials, EarlyView.
The work demonstrates that strategic wall‐thickness grading in diamond triply periodic minimal surface lattices enables precise tuning of deformation and failure behavior under compression. Different gradation patterns guide how and where the structure collapses, improving energy absorption or promoting controlled brittle failure.
Giovanni Rizza   +3 more
wiley   +1 more source

A Survey of Two Optimization Methods to Solve a Modified Minimal Spanning Tree Problem in Undirected Tree Graph [PDF]

open access: yesAl-Rafidain Journal of Computer Sciences and Mathematics, 2011
The paper tackled a survey of two optimization methods to study spanning tree problem by modifying the   spanning tree problem to generate all of possible solutions in undirected tree graph with simulated annealing algorithm and ant colony optimization ...
Isra Alkallak, Ruqaya Sha’ban
doaj   +1 more source

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