Results 41 to 50 of about 16,728 (249)

SpaK/SpaR two-component system characterized by a structure-driven domain-fusion method and in vitro phosphorylation studies. [PDF]

PLoS Computational Biology, 2009
Here we introduce a quantitative structure-driven computational domain-fusion method, which we used to predict the structures of proteins believed to be involved in regulation of the subtilin pathway in Bacillus subtilis, and used to predict a protein ...
Anu Chakicherla, Carol L Ecale Zhou, Martha Ligon Dang, Virginia Rodriguez, J Norman Hansen, Adam Zemla   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Numerical simulation of vertex induced motion for Spar platform with helical strakes

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] Long-lasting Vortex Induced Motion(VIM)may cause the Spar platform mooring system fatigue and even the structure damage. Therefore,the adverse effects of VIM must be fully taken into account.[Methods] In this paper,the CFD solver naoe-FOAM ...
He Jiawei, Zhao Weiwen, Wan Decheng
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

ÜNİVERSİTE ÖĞRENCİLERİNİN SPORA KATILIM DÜZEYLERİNİN BELİRLENMESİ

Research in Sports Science, 2013
Bireylerin spora katılımı, modernleşme süreci içerisinde yer alan toplumlar açısından son derece Önemli bir fonksiyon halini almıştır. Spora katılımın nitelik ve nicelik olarakboyutlarının belirlenmesi, konuya ilişkin yatırımların daha bilinçli olarak ...
FERUDUN DORAK, TİMUÇİN GENÇER
doaj  

Spar caves as fossil hydrothermal systems: Timing and origin of ore deposits in the Delaware Basin and Guadalupe Mountains, New Mexico and Texas, USA

International Journal of Speleology, 2018
Studies of sulfuric acid hypogene speleogenesis have contributed significantly to understanding the history of the Guadalupe Mountains of southeast New Mexico and west Texas for at least the past 12 Ma.
David D. Decker, Victor J. Polyak, Yemane Asmerom   +2 more
doaj   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

IMPLEMENTING R5 AND KIVA IN WAREHOUSE MANAGEMENT A CASE EXAMPLE FOR SPAR IKEJA, NIGERIA

Modern Management Review
The logistics of any superstore chain is its ability to get the products at the shelves which their customers really want. The SPAR Nig ltd is a limited liability company operating in Nigeria under license from its South Africa conglomerate whose ...
Justin Ogala S. EGBUNU
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source