Results 171 to 180 of about 609 (256)

Microbialite Diversity and Ocean Redox Geochemistry of the Late Tonian Callison Lake Formation. [PDF]

open access: yesGeobiology
Spruzen C   +5 more
europepmc   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang   +3 more
wiley   +1 more source

The Subhyoid Approach for Base of Tongue Tumors: Description of A Novel Surgical Technique

open access: yesThe Laryngoscope, EarlyView.
The sub‐hyoid approach is a novel open surgical technique for selected deeply infiltrative base of tongue tumors, providing direct access and allowing full‐thickness resection while preserving the tongue neurovascular structures. Thyro‐hyoido‐pexy restores hyo‐laryngeal suspension without flap reconstruction, with the aim of preserving swallowing ...
Livio Presutti   +6 more
wiley   +1 more source

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir   +4 more
wiley   +1 more source

A plant–pollinator invasional meltdown: the Japanese pagoda tree Styphnolobium japonicum facilitates the invasion of the giant resin bee Megachile sculpturalis

open access: yesOikos, EarlyView.
An invasional meltdown can occur when a non‐native species facilitates the spread of another non‐native species in the invaded area, increasing its likelihood of survival or its ecological impact. Plant–pollinator systems pose an exceptional study system to test this concept, which remains poorly known.
Daniel Echeandía   +9 more
wiley   +1 more source

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