Results 131 to 140 of about 29,961 (262)
Cross‐species network analysis identifies CCN1/2 as conserved hubs linking extracellular matrix assembly, growth factor signaling, and mechanosensitive pathways during chondrogenesis, guiding model selection and informing CCN‐targeted cartilage regeneration strategies.
Zhangzheng Wang +9 more
wiley +1 more source
SpaRCe : sparse reservoir computing [PDF]
"Sparse" neural networks, in which relatively few neurons or connections are active, are common in both machine learning and neuroscience. Whereas in machine learning, "sparseness" is related to a penalty term which effectively leads to some connecting weights becoming small or zero, in biological brains, sparseness is often created when high spiking ...
Manneschi, L., Lin, A.C., Vasilaki, E.
openaire +2 more sources
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo +3 more
wiley +1 more source
In IgG4‐related disease, the epithelial‐to‐mesenchymal transition of fibroblasts was predominantly driven by transforming growth factor‐β1 secreted from CD19+ B cells. Reciprocally, fibroblasts facilitated CD19+ B‐cell survival and activation through CXCL14–CXCR4 and CXCL12–CXCR4 signalling axes, thereby promoting B‐cell responses and subsequent ...
In‐Woon Baek +2 more
wiley +1 more source
Report on the 5th SPARC General Assembly
Beautiful Queestown, New Zealand, was hot to the nearly 300 scientists from around the globe that came together to participate in the 5th SPARC General Assembly in 2008 meant that a lot has happened since SPARC hat its last "family reunion" in Bologna ...
Sato, K. +24 more
core
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
Affinity tuning of anti‐HLA‐A2 CARs reveals that lower‐affinity CAR‐Tregs exhibit reduced avidity and enhanced serial engagement, leading to increased activation and trogocytosis. These properties promote improved tissue infiltration, persistence, and survival in vivo, demonstrating that optimizing receptor–antigen dynamics enhances the therapeutic ...
Ada Sera Kurt +12 more
wiley +1 more source
Integrating multiplexed immunofluorescence, animal models, and clinical samples, our single‐cell and spatial atlas maps tumor microenvironment evolution during bladder cancer (BCa) progression. We reveal that stemness‐associated tumor cells (SDC1+), POSTN+ myofibroblastic cancer‐associated fibroblasts (mCAFs), and immunosuppressive monocytic myeloid ...
Ting Liang +13 more
wiley +1 more source
DSpace for e-print archives [PDF]
DSpaceTM (http://dspace.org/) is the new open source digital repository system from the MIT Libraries and Hewlett-Packard Labs designed to support the digital collections of academic research institutions, as well as the SPARC conception of Institutional
Smith, MacKenzie
core

