Results 41 to 50 of about 1,593 (185)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

A large-scale retrospective study of opioid poisoning in New York State with implications for targeted interventions

Scientific Reports, 2021
Opioid overdose related deaths have increased dramatically in recent years. Combating the opioid epidemic requires better understanding of the epidemiology of opioid poisoning (OP).
Xin Chen, Wei Hou, Sina Rashidian, Yu Wang, Xia Zhao, George Stuart Leibowitz, Richard N. Rosenthal, Mary Saltz, Joel H. Saltz, Elinor Randi Schoenfeld, Fusheng Wang   +10 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Patient characteristics of seven types of cancer in SPARCS, 2011-2015.

, 2018
Patient characteristics of seven types of cancer in SPARCS, 2011-2015.
Fusheng Wang (102710), Yu Wang (12152), Wei Hou (48073)   +2 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

The Star-Planet Activity Research CubeSat (SPARCS): Determining Inputs to Planetary Habitability

, 2022
Seventy-five billion low-mass stars in our galaxy host at least one small planet in their habitable zone (HZ). The stellar ultraviolet (UV) radiation received by the planets is strong and highly variable, and has consequences for atmospheric loss ...
Peacock, Sara, Struebel, Nathaniel, Ardila, David R., Cheng, Samuel, Gregory, Dawn, Barman, Travis, Ramiaramanantsoa, Tahina, Shkolnik, Evgenya, Gamaut, Jonathan, Scowen, Paul, Jacobs, Daniel, Loyd, R. O. Parke, Meadows, Victoria, Kolopanis, Matthew, Bowman, Judd, Knapp, Mary, Jewell, April, Nikzad, Shouleh, Basset, Christopher, Jensen, Logan, Llama, Joseph, Swain, Mark   +21 more
core  

Evaluating Approximations of River Channel Shape Using a National Cross‐Section Database

Water Resources Research
Many hydrologic applications require basic information on the size and shape of river channels, but measuring cross section (XS) geometry in the field or via remote sensing can be costly and often provides only partial coverage.
C. J. Legleiter, P. J. Kinzel
doaj   +1 more source

Impact of Iron Deficiency Anemia on Postoperative Outcomes of Thoracolumbar Spinal Fusion (2+ levels) on Patients with Adult Spinal Deformity with Minimum 2-Year Follow-Up

Spine Surgery and Related Research
Introduction: Iron deficiency anemia (IDA) is a common hematological disorder and cause of low hemoglobin. Preoperative anemia has been demonstrated to increase the risk of adverse outcomes after posterior cervical fusion and other spinal surgeries.
Alex C. Jung, Olivia Tracey, Ryan Kong, Neil Patel, Bana Hadid, Chibuokem Ikwuazom, Neil Shah, Carl Paulino, Jad Bou Monsef   +8 more
doaj   +1 more source

Association of Magnet Status With Hospitalization Outcomes for Ischemic Stroke Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIt is not clear whether Magnet recognition by the American Nurses Credentialing Center (nursing excellence program) is associated with improved patient outcomes.
Kimon Bekelis, Symeon Missios, Todd A. MacKenzie   +2 more
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source