IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Spare Parts Demand Forecasting Method Based on Intermittent Feature Adaptation. [PDF]
Entropy (Basel), 2023 Fan L, Liu X, Mao W, Yang K, Song Z.
europepmc +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Additive manufacturing for maritime spare parts supply: An overview [PDF]
, 2016 Additive Manufacturing (AM), also called 3D Printing (3DP) is not a new technology. The technology was invented over 30 years ago. Originally thought of as simply an application for rapid prototyping, it has developed significantly and is now a viable ...
Ye, Jilin
core
Intraoperative "Spare Parts": A Novel High-fidelity Suturing Model for Trainees. [PDF]
Plast Reconstr Surg Glob Open, 2022 Pardell N, Dumestre D.
europepmc +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Osteocutaneous Turn-Up Fillet Flaps: A Spare-Parts Orthoplastic Surgery Option for a Functional Posttraumatic Below-Knee Amputation. [PDF]
Arch Plast Surg, 2023 Burton H +6 more
europepmc +1 more source
Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani +10 more
wiley +1 more source
, 2009 The role of spare parts management and low turnaround parts and components in production systems is discussed by several research contributions as reported in the literature. A few studies explicitly measure the role and effects of spare parts management
BINDI F. +6 more
core +1 more source
Recognition of Industrial Spare Parts Using an Optimized Convolutional Neural Network Model
InformationSpare parts search and retrieval processes are of paramount importance in manufacturing and supply chains. Image recognition using 2D and 3D image properties plays an important part in the success of such processes, as it facilitates the identification ...
Chandralekha Mohan +2 more
doaj +1 more source