Results 201 to 210 of about 50,718 (252)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Genome-Wide Association Mapping of Low-Nitrogen Tolerance in Hexaploid Oat Identifies a Suggestive Candidate Locus near <i>P5CDH</i> Associated with Root Dry Weight. [PDF]

Genes (Basel)
Ling Y, Wang Z, Yu S, Zhang Z, Yang H, Zhang L.   +5 more
europepmc   +1 more source

Neuromorphic Optical Tracking and Imaging of Randomly Moving Targets Through Dynamic Dense Scattering Media

Advanced Science, EarlyView.
Vision begins not with images but with change: the retina fires only when something moves, handing the brain a stream of spikes. A neuromorphic imaging system adopts the same strategy—an event sensor that sees like the retina, a spiking network that thinks like the brain—to track and reconstruct fully randomly moving targets through tissue (phantom ...
Ning Zhang, Arto Nurmikko
wiley   +1 more source

Pre-Thrombolysis Biological Correlates of Admission Glasgow Coma Scale in Older Adults with Acute Ischemic Stroke: A Retrospective Single-Center Cohort Study. [PDF]

Medicina (Kaunas)
Munteanu SN, Stan A, Nechita A, Firescu D, Marinescu MC, Tanase CE, Navalici I, Tutunaru D, Moisei M, Romila A.   +9 more
europepmc   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Modelling time-varying genetic effects on binary disease risk via functional Mendelian randomization. [PDF]

Bioinformatics
Fontana N, Secchi P, Di Angelantonio E, Ieva F.   +3 more
europepmc   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Poly pipeline: a polyvalent spatial transcriptomics workflow validated across polyploid and diploid organisms. [PDF]

GigaByte
Carvalho PC, MIllsteed T, Henry RJ.
europepmc   +1 more source

Zolbetuximab-associated adverse event reporting signals in gastric cancer: a FAERS disproportionality analysis. [PDF]

Front Pharmacol
Zhang J, Zhen Z, Li Z, Zhu P.
europepmc   +1 more source