Results 211 to 220 of about 379,537 (253)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Sparse Regression Based Structure Learning of Stochastic Reaction Networks from Single Cell Snapshot Time Series. [PDF]

PLoS Comput Biol, 2016
Klimovskaia A, Ganscha S, Claassen M.
europepmc   +1 more source

Innovative Metasurface Colorimetric Cell‐on‐a‐Chip Sensor for Continuous, Label‐Free, Non‐Destructive Assessment of Intestinal Barrier Dynamics

Advanced Science, EarlyView.
We developed a real‐time, label‐free, high‐throughput cell‐on‐a‐chip system based on a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) to evaluate intestinal barrier function. This platform enables continuous monitoring of cell adhesion, proliferation, and barrier layer formation, disruption, and repair.
Youqian Chen, Wen Li, Jiaying Feng, Yue Shu, Yihui Yang, Yuyan Wang, Rui Li, Hanlin Zhou, Xinfan Yang, Yuxue Guo, Mingqian Chen, Wenjun Hu, Gang Logan Liu, Liping Huang, Yanan Li   +14 more
wiley   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source

Probabilistic Air Segmentation and Sparse Regression Estimated Pseudo CT for PET/MR Attenuation Correction. [PDF]

Radiology, 2015
Chen Y, Juttukonda M, Su Y, Benzinger T, Rubin BG, Lee YZ, Lin W, Shen D, Lalush D, An H.   +9 more
europepmc   +1 more source

Emerging Advanced Electronic Packaging Materials for Thermal Management in Power Electronics

Advanced Science, EarlyView.
This review surveys emerging materials for thermal management in advanced electronic packaging, with emphasis on ceramic substrates and thermal interface materials. Multiscale simulations and mechanistic analyses are highlighted, alongside the emerging role of artificial intelligence in predicting thermal properties and guiding design, offering ...
Yongjun Huo, Jiaqi Song, Wenqian Li, Jian Zhang, Yujin Zhang, Yang Fu, Wangchao Yuan, Xin Chen, Sichen Liu, Miao Jiang, Yuan Cheng, Gang Zhang   +11 more
wiley   +1 more source

AP‐Lab: An AI‐Driven Autonomous Pilot‐Scale Platform Bridging Materials Discovery and Industrial Manufacturing

Advanced Science, EarlyView.
AP‐Lab bridges materials discovery and industrial manufacturing by coupling proprietary datasets with an application benchmark (PCR Ct). A closed‐loop optimization workflow integrates ML, LLM, and autonomous synthesis/testing to refine magnetic nanoparticles–based nucleic‐acid extraction systems.
Zhan‐Long Wang, Zhifen Ma, Wenxing Song, Guolai Jiang, Boshi Jiang, Mingyang Jiang, Weiliang Shu, Bing Wang, Zhiyuan Wan, Shengyong Geng, Zhen Zhao, Wenhua Zhou, Xue‐Feng Yu   +12 more
wiley   +1 more source