Results 131 to 140 of about 15,887 (242)
Helmeted hornbill cranial kinesis: Balancing mobility and stability in a high‐impact joint
Abstract Prokinesis—in which a craniofacial joint allows the rostrum to move relative to the braincase—is thought to confer diverse advantages in birds, mostly for feeding. A craniofacial joint would, however, be a weak link if cranial stability is important. Paradoxically, we have identified a craniofacial joint in helmeted hornbills (Rhinoplax vigil),
Mike Schindler +8 more
wiley +1 more source
ABSTRACT Purpose To achieve high resolution (≤ 1 mm isotropic) whole‐brain perfusion imaging at 7 T with next generation ASL pulse sequence, reconstruction algorithm, and MRI hardware. Methods We capitalized on three major innovations: (1) FLASH‐based pseudo‐Continuous ASL (pCASL) sequence with rotated golden‐angle stack‐of‐spirals (rGA‐SoS) sampling; (
Chenyang Zhao +8 more
wiley +1 more source
Abstract Background Despite growing concerns about antimicrobial resistance, prophylactic antimicrobials continue to be routinely administered in many procedures, including dental extractions. Further evidence‐based research is needed on whether their use influences post‐operative complication rates.
Marlies Schnierer +4 more
wiley +1 more source
Multiomics Research Strategies in Cancer: A Growing and Innovative Field
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du +8 more
wiley +1 more source
ABSTRACT Purpose To demonstrate the feasibility of a novel dual‐phase self‐navigated, free‐breathing balanced steady‐state free‐precession whole‐heart MRA acquisition for aortic annulus size measurement using a Cartesian trajectory that mitigates eddy‐current artifacts by minimizing k‐space jumps between consecutive readouts with predictable scan times.
Tassia Ribeiro Salles Moura +11 more
wiley +1 more source
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Sparse Logistic Regression-Based One-Bit SAR Imaging
Shaodi Ge +4 more
openaire +1 more source
ABSTRACT This review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for absorption, distribution, metabolism, and excretion (ADME) properties across drug development ...
Xinyue Chen, Zhoumeng Lin
wiley +1 more source
Abstract On 7–8 January, 2025, the Eaton fire destroyed >9,000 structures and >40 km2 of forest in the northeastern region of the Los Angeles metropolitan area, California. Building damage was primarily assessed through ground investigations, a process that took several weeks due to hazardous conditions and the difficulty of accessing burnt areas. This
Solene L. Antoine
wiley +1 more source
Abstract Artificial‐intelligence weather prediction models have recently surpassed numerical models in large‐scale skill, but they still systematically underestimate typhoon intensity due to their reliance on coarse‐resolution training data from ERA5. To overcome this limitation, we constructed a bespoke 9‐km high‐resolution typhoon reanalysis (HiRes ...
Zeyi Niu +8 more
wiley +1 more source

