Results 171 to 180 of about 20,469 (205)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Direct FFT oversampling without zero-padding. [PDF]

Sci Rep
Donciu C, Temneanu MC, Serea E.
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Butler-Matrix Beamspace Front-Ends for Massive MIMO: Architecture, Loss Budget, and Capacity Impact. [PDF]

Sensors (Basel)
Vico F, Monserrat JF, Ge Y.
europepmc   +1 more source

Comparative effectiveness of antibiotic prophylaxis for preventing serious adverse events after primary total hip arthroplasty: a systematic review and network meta-analysis of randomized trials. [PDF]

Acta Orthop
Abedi AA, Svensson JM, Pedersen AB, Varnum C, Nielsen SM, Laigaard JH, Christensen R, Overgaard S.   +7 more
europepmc   +1 more source

Biobjective gradient descent for feature selection on high dimension, low sample size data. [PDF]

PLoS One
Issa T, Angel E, Zehraoui F.
europepmc   +1 more source

Efficient structure learning of gene regulatory networks with Bayesian active learning. [PDF]

BMC Bioinformatics
Sándor D, Antal P.
europepmc   +1 more source

Oxytocin enhances creativity specifically in approach-motivated individuals. [PDF]

Soc Cogn Affect Neurosci
Yang C, Guo Z, Cheng L.
europepmc   +1 more source

Effectiveness of emergency surgeries performed by nurse-surgeons and other non-physician providers: a systematic review and proportional meta-analysis. [PDF]

BMC Nurs
El-Banna MM, Shaik RA, Sajid MR, Sami W, McNelis AM.   +4 more
europepmc   +1 more source