Results 71 to 80 of about 134,382 (360)

MGPT: A Multi‐task Graph Prompt Learning Framework for Drug Discovery

Advanced Science, EarlyView.
MGPT is a unified multi‐task graph prompt learning model providing generalizable and robust graph representations for few‐shot drug association prediction. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few‐shot scenarios.
Yang Li, Youhan Sun, Xinyu Qin, Xin Gao, Guohua Wang   +4 more
wiley   +1 more source

Angina Severity and Symptom Improvement Are Associated With Diagnostic Acetylcholine Provocation Dose in Vasospastic Angina

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A coronary function test (CFT) is the recommended diagnostic test to identify coronary vasomotor dysfunction as a cause of symptoms in patients with angina and nonobstructive coronary arteries (ANOCA).
C. Crooijmans, Tijn P. J. Jansen, Joan G. Meeder, Valeria Paradies, Annemiek M. J. de Vos, Pier Woudstra, Tessel N. E. Vossenberg, Tim P. van de Hoef, Nicola S. Vos, Els G. M. Olde Bijvank, Stijn C. H. van den Oord, Patty Winkler, Martijn Meuwissen, Jos W. M. G. Widdershoven, E. Karin Arkenbout, Martin G. Stoel, Yolande Appelman, Marcel A. M. Beijk, Aysun Cetinyurek‐Yavuz, Hester M. den Ruijter, Suzette E. Elias‐Smale, Niels van Royen, Aukelien C. Dimitriu‐Leen, Peter Damman   +23 more
doaj   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

F波、H反射在卒中后肢体痉挛疗效评估中的研究进展 Progress of F Wave and H Reflex in Effect Evaluation of Antispastic Treatment of Limb Spasticity in Post-stroke Patients

Zhongguo cuzhong zazhi, 2018
卒中后肢体痉挛是上运动神经元损伤导致高级中枢失去对脊髓牵张反射的抑制，脊髓 反射性增高引起以牵张反射增强为特征的肌肉张力异常。肢体痉挛是卒中后常见并发症之一，严重影 响了卒中患者功能康复。近年来涌现出各类改善卒中后肢体痉挛的治疗方法，但其疗效评价标准不 一，其中以主观性量表评价为主。笔者搜集了近些年国内外卒中后肢体痉挛治疗的临床研究文献，发 现F波、H反射相关参数等客观评价指标被越来越多地与主观评价量表相结合，运用到各类临床研 究的疗效评价中。相对于H反射，F波具有更加灵敏的特点 ...
李焕芹*，龙德怀*，李彬，孙敬青，温雅丽，刘银霞，杜红燕，王麟鹏（*第一作者）
doaj   +1 more source

PENGARUH TEKNIK EKSTUBASI TERHADAP KEJADIAN SPASME LARING PADA OPERASI TONSILEKTOMI [PDF]

, 2007
Background: Laryngeal spasm is the most common cause of airway obstruction after extubation in general anesthesia, particularly on airway surgery such as tonsillectomy and adenoidectomy, the incidence rates 21-28%.
Mahardhika, Aria_Windy
core  

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Case Report: Hypomyelinating Leukodystrophy Type 20 (HLD20) With Novel CNP Gene Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This case report describes a child with hypomyelinating leukodystrophy type 20 (HLD20), a rare neurodegenerative disorder characterized by impaired myelin formation. The patient presented with multiple neurodevelopmental abnormalities, including delayed motor milestones, seizures, and abnormal facial features.
Malak Alghamdi, Ghaida Alghamdi, Khalid Hundallah, Dima Jamjoom, Naif Almontashiri, Essa Alharbi, Muhammad Umair, Majid Alfadhel   +7 more
wiley   +1 more source

An Introduction of IMS(Intramuscular Stimulation Therapy) with Theoretcial Basis and Clinical Applications

Journal of Pharmacopuncture, 2003
Results : 1. The most important concept of IMS is chronic pain illness that may develop into hypersensitivity of the nerves, i.e., neuropathy. 2. Muscle shortening may be triggered by stress, including emotional, physical, external, and internal factors.
Ki-Rok Kwon, Kyung-Seung Gok, Sung-wook Kim   +2 more
doaj   +1 more source

The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glycogen storage disorders are a group of genetic disorders affecting glucose homeostasis in the body. Muscular glycogen stores are essential for liberating glucose for energy supply during bursts of activity and sustained muscle work. Muscle glycogen storage disease 0 (GSD0B) is associated with biallelic variants in GYS1 causing muscular ...
Sarah Donoghue, Smitha Kumble, Pontus Wasling, Lars Alberg, Pia Linton‐Dahlöf, Yilmaz Yildiz, İlker Ertuğrul, Terry Derks, Dwight Koeberl, Emmeline Lagrange, Sabrina Vergnaud, Lidia Pezzani, Maria Iascone, Zornitza Stark, Adam M. Bournazos, Sandra T. Cooper, Gittan Kollberg   +16 more
wiley   +1 more source

Fluctuation of spastic location in patients with vasospastic angina: A quantitative angiographic study [PDF]

, 1995
Objectives.: This study sought to determine whether the location of coronary spastic activity may change over time in patients with persistent variant angina.
Keane, D.T.J. (David), Ozaki, Y. (Yukio), Serruys, P.W.J.C. (Patrick)   +2 more
core   +1 more source