Results 281 to 290 of about 121,621 (353)

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Regional Anesthesia With Levobupivacaine in a Patient With a RyR2 Gene Mutation After Cardiac Arrest: A Case Report. [PDF]

Cureus
Sreckovic S, Lemic J, Vitomirovic K, Vukman P, Glisovic Jovanovic I.   +4 more
europepmc   +1 more source

Efficacy and Safety of Combined Treatment with Traditional Herbal Medicine and Western Medicine for Children with Pertussis-like Syndrome: Systematic Review and Meta-Analysis. [PDF]

Healthcare (Basel)
Choi JU, Shim YS, Kim EJ, Min SY.
europepmc   +1 more source

‘No man's land’: the journey of young adults with complex care needs, from paediatric to adult healthcare

Internal Medicine Journal, EarlyView.
Abstract Background Transition to adulthood can be a challenging time. For people with complex health needs, there is an additional burden of navigating a fragmented healthcare system. Aims To identify the challenges faced by young people with complex health needs in the transition journey from their perspective.
Josephine Thomas, Jemma Anderson, Betty‐Jean Dee‐Price, Janet Kelly, Kate Turpin   +4 more
wiley   +1 more source

Ubiquitin-Associated Protein 1 (UBAP1) Gene Mutation in a 36-Year-Old Filipino Male With Spastic Paraplegia: A Case Report. [PDF]

Cureus
Solijon KKL, Abejero JEE.
europepmc   +1 more source

Medicinal cannabis: is current use clinically justified?

Internal Medicine Journal, EarlyView.
Abstract Cannabis products are increasingly perceived and advertised as natural and safe treatments for a variety of conditions, including chronic non‐cancer pain (CNCP). The number of prescriptions for medicinal cannabis (MC) currently averages >80 000 per month for >1 million Australians. Although over 800 different cannabis products are available to
Russ J. Scott, Ian A. Scott
wiley   +1 more source

Real-life management of nonobstructive esophageal dysphagia: analysis of a prospective multicentric Portuguese cohort. [PDF]

Therap Adv Gastroenterol
Mendes RR, Rodrigues JP, Simão I, Lima H, Guedes T, Barrias S, Costa MS, Souto P, Silva JC, Correia J, Morão B, Revés J, Leal C, Curto JD, Marinho RT, Mascarenhas Saraiva M.   +15 more
europepmc   +1 more source

Gaucher disease, state of the art and perspectives

Journal of Internal Medicine, EarlyView.
Abstract Knowledge about Gaucher disease (GD), considered a model for rare diseases, has considerably increased since its discovery. The pathophysiology of this lysosomal disorder is better known, and specific therapies that can control many aspects of the disease have been developed, particularly for the most common form, Type 1 GD.
Fabrice Camou, Marc G. Berger
wiley   +1 more source