Results 181 to 190 of about 6,899,247 (329)

Network models for bridging denoising and identifying spatial domains of spatially resolved transcriptomics. [PDF]

PLoS Comput Biol
Wang H, Zhang W, Liu Z, Ma X.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Spatial econometric analysis of health workforce distribution and its influencing factors in Inner Mongolia, China. [PDF]

PLoS One
Hu J, Xu L, Li X, Liu S.
europepmc   +1 more source

Pandemic Injustice: Spatial and Social Distributions of COVID-19 in the US Epicenter

, 2020
Timon McPhearson, Zbigniew R. Grabowski, Pablo Herreros‐Cantis, Ahmed Mustafà, Luis Ortiz, Christopher Kennedy, Claudia Tomateo, Bianca Lopez, Veronica Olivotto, Avigail Vantu   +9 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Study on the relationship between PM2.5 concentration and intensive land use in Hebei Province based on a spatial regression model

, 2020
Jingjing Shao, Jingfeng Ge, Xiaomiao Feng, Chaoran Zhao   +3 more
openalex   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Spatial modelling improves genomic evaluation in Tanzanian smallholder admixed dairy cattle. [PDF]

Genet Sel Evol
Houaga I, Mrode R, Ojango J, Ekine-Dzivenu CC, Okeyo M, Nziku Z, Nguluma A, Lavrenčič E, Lindgren F, Pocrnic I, Djikeng A, Gorjanc G.   +11 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

SpaLLM: a general framework for spatial domain identification with large language models. [PDF]

Front Bioinform
Zou Z, Duan Z.
europepmc   +1 more source