Results 111 to 120 of about 5,620,672 (313)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial attention and conscious perception: interactions and dissociations between and within endogenous and exogenous processes

, 2012
A current controversy exists about the relationship between spatial attention and conscious perception. While some authors propose that these phenomena are intimately related (Bartolomeo, 2008; Chun & Marois, 2002; O'Regan & Noë, 2001; Posner, 1994 ...
Bartolomeo, Paolo
core   +1 more source

Human frontal eye fields and spatial priming of pop-out [PDF]

, 2007
"Priming of pop-out" is a form of implicit memory that facilitates detection of a recently inspected search target. Repeated presentation of a target's features or its spatial position improves detection speed (feature/spatial priming).
Neil G. Muggleton, Muggleton, NG, Jacinta O'Shea, Cowey, A, Alan Cowey, O'Shea, Jacinta, O'Shea, J, Walsh, V, Cowey, Alan, Vincent Walsh   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Differing effects of attention in single-units and populations are well predicted by heterogeneous tuning and the normalization model of attention

Frontiers in Computational Neuroscience, 2014
Single-unit measurements have reported many different effects of attention on contrast-response (e.g. contrast-gain, response-gain, additive-offset dependent on visibility), while functional imaging measurements have more uniformly reported increases in ...
Yuko eHara, Franco ePestilli, Franco ePestilli, Justin L Gardner   +3 more
doaj   +1 more source

Spatial models for context-aware indoor navigation systems: A survey [PDF]

, 2012
This paper surveys indoor spatial models developed for research fields ranging from mobile robot mapping, to indoor location-based services (LBS), and most recently to context-aware navigation services applied to indoor environments.
Christophe Claramunt, Imad Afyouni, Christophe, Claramunt, RAY, Cyril, Cyril Ray, AFYOUNI, Imad, CLARAMUNT, Christophe   +6 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Color-selective attention need not be mediated by spatial attention

Journal of Vision, 2009
It is well-established that attention can select stimuli for preferential processing on the basis of non-spatial features such as color, orientation, or direction of motion. Evidence is mixed, however, as to whether feature-selective attention acts by increasing the signal strength of to-be-attended features irrespective of their spatial locations or ...
Søren K, Andersen, Matthias M, Müller, Steven A, Hillyard   +2 more
openaire   +2 more sources

Spatial attention shifting and phonological processing in adults with dyslexia [PDF]

, 2015
According to Hari and Renvall’s (2001) sluggish attentional shifting (SAS) hypothesis people with dyslexia have a central deficit in attention shifting.
Larkin, RF, Abbott, I, Dunn, AK
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source