Results 91 to 100 of about 3,451,908 (311)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Spatial compatibility with a two-dimensional stimulus arrangement. [PDF]

open access: yesBulletin of the Psychonomic Society, 1984
In this study, spatial compatibility of two-dimensional stimulus arrays versus one-dimensional response and effector arrays was investigated. A two-choice reaction time task was performed with rotating stimuli arranged on the periphery of a black vertical disk. Response was bimanual, with a crossed- and uncrossed hands condition.
Soetens, Eric, Hueting, Johan
openaire   +3 more sources

Underactuated Spatial Mechanism of Vehicle Door Latch with Force Constraint

open access: yesJixie chuandong, 2021
Aiming at less space occupation,efficient driving and high-end multi-function of the door latch release branch chain,the type synthesis of single loop spatial mechanism is carried out,and the RRRSR mechanism which could realize power release is obtained.
Sulong Li   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Characteristics and Influencing Factors of Rural Industrial Integration Land in China: A Case Study in Qingdao, Shandong Province

open access: yesLand
Rural industrial integration land has emerged with the rise of new industries in rural China, exhibiting spatial distribution patterns distinct from traditional industrial land. However, research on this land use remains limited.
Bailin Zhang   +4 more
doaj   +1 more source

Exploring the Role of Action Consequences in the Handle-Response Compatibility Effect

open access: yesFrontiers in Human Neuroscience, 2020
Previous research investigating handle-response compatibility effects with graspable objects used different categories of objects as stimuli, regardless of their specific, intrinsic characteristics.
Elisa Scerrati   +7 more
doaj   +1 more source

High-resolution transport-of-intensity quantitative phase microscopy with annular illumination

open access: yes, 2017
For quantitative phase imaging (QPI) based on transport-of-intensity equation (TIE), partially coherent illumination provides speckle-free imaging, compatibility with brightfield microscopy, and transverse resolution beyond coherent diffraction limit ...
Asundi, Anand   +5 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Spatial Planning in Protected Areas: Conceptualization and a Multi-Criteria Compatibility Assessment Model Applied to Kozara National Park

open access: yesLand
Cultural and natural heritage are increasingly framed as components of territorial governance rather than isolated conservation elements; yet, a structural gap persists between their strategic recognition in planning documents and their measurable ...
Neda Živak   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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