Results 51 to 60 of about 55,065 (256)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Perceived Ownership of Avatars Influences Visual Perspective Taking
Frontiers in Psychology, 2018 Modern computer-based applications often require the user to interact with avatars. Depending on the task at hand, spatial dissociation between the orientations of the user and the avatars might arise. As a consequence, the user has to adopt the avatar’s
Christian Böffel, Jochen Müsseler
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Automatic imitation and spatial compatibility in a key-pressing task
Acta Psychologica, 2012 Automatic imitation has been often confounded with spatial compatibility effects. Heyes (2011) called attention to this confound, and proposed some criteria which must be satisfied before these effects could be unequivocally taken to be an index of the functioning of the human mirror system. Evidence satisfying such criteria has been reported by Catmur
Luis, Jiménez +5 more
openaire +2 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Exploring the role of verbal-semantic overlap in response-effect compatibility
Acta Psychologica, 2021 According to ideomotor accounts, actions are cognitively represented by their sensory effects. The response-effect compatibility (R-E compatibility) paradigm investigates this notion by presenting predictable effect stimuli that are produced by the ...
Iring Koch +3 more
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
LandRural industrial integration land has emerged with the rise of new industries in rural China, exhibiting spatial distribution patterns distinct from traditional industrial land. However, research on this land use remains limited.
Bailin Zhang +4 more
doaj +1 more source
Underactuated Spatial Mechanism of Vehicle Door Latch with Force Constraint
Jixie chuandong, 2021 Aiming at less space occupation，efficient driving and high-end multi-function of the door latch release branch chain，the type synthesis of single loop spatial mechanism is carried out，and the RRRSR mechanism which could realize power release is obtained.
Sulong Li +3 more
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