Results 151 to 160 of about 226,967 (265)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A research on spatial configuration characteristics and social performance evaluation of public sports facilities in shanghai based on geographic information system (GIS). [PDF]

PLoS One
Li H, Li L, Li Y, Ji Q, Zhao J, Ge Z, Zhou Q, Sun Q.   +7 more
europepmc   +1 more source

Spatial configuration matters when removing windfelled trees to manage bark beetle disturbances in Central European forest landscapes. [PDF]

J Environ Manage, 2020
Dobor L, Hlásny T, Rammer W, Zimová S, Barka I, Seidl R.   +5 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A multi-objective approach for timber harvest scheduling to include management of at-risk species and spatial configuration objectives. [PDF]

PLoS One
Jones MD, Larsen-Gray A, Prisley SP, Munro HL, Hunter EA.   +4 more
europepmc   +1 more source

The spread of presaccadic attention depends on the spatial configuration of the visual scene. [PDF]

Sci Rep, 2019
Szinte M, Puntiroli M, Deubel H.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Optimized Spatial Configuration of Heterogeneous Biocatalysts Maximizes Cell-Free Biosynthesis of ω-Hydroxy and ω-Amino Acids. [PDF]

ACS Sustain Chem Eng
Santiago-Arcos J, Velasco-Lozano S, Diamanti E, Benítez-Mateos AI, Grajales-Hernández D, Paradisi F, López-Gallego F.   +6 more
europepmc   +1 more source

Discrimination of changes in spatial configuration for multiple, simultaneously presented sounds. [PDF]

J Acoust Soc Am, 2019
Yost WA, Pastore MT, Zhou Y.
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source