Results 171 to 180 of about 8,118,965 (303)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Unraveling lncRNA diversity at a single cell resolution and in a spatial context across different cancer types. [PDF]

Nat Methods
Prakrithi P, Vo T, Xiong Z, Vu H, Nguyen LT, Newman A, Wilhelmey J, Whitehall V, Cruz JLG, Wood S, Mallett AJ, Gupta I, Nguyen Q.   +12 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Efficient industrial point cloud anomaly detection via spatial context aggregation and selective anomalous feature generation. [PDF]

Sci Rep
Hoang DC, Tan PX, Nguyen AN, Le M, Duong THA, Huynh TM, Nguyen DM, Cao MD, Ngo DH, Vu MQ, Nguyen TU, Phan KT, Do MQ, Dinh XT, Duong VH, Nguyen VT.   +15 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Multi-Class Cell Detection Using Spatial Context Representation. [PDF]

Proc IEEE Int Conf Comput Vis, 2021
Abousamra S, Belinsky D, Van Arnam J, Allard F, Yee E, Gupta R, Kurc T, Samaras D, Saltz J, Chen C.   +9 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Anterior insular activity signals perceptual conflicts induced by temporal and spatial context. [PDF]

Neurosci Conscious
Reichenbach K, Rothkirch M, Jaeckel L, Sterzer P, Weilnhammer V.   +4 more
europepmc   +1 more source

Dynamic heterogeneity of colorectal cancer during progression revealed clinical risk-associated cell types and regulations in single-cell resolution and spatial context. [PDF]

Gastroenterol Rep (Oxf), 2023
Ke H, Li Z, Li P, Ye S, Huang J, Hu T, Zhang C, Yuan M, Chen Y, Wu X, Lan P.   +10 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source