Results 121 to 130 of about 26,522,155 (308)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

An All-Time-Domain Moving Object Data Model, Location Updating Strategy, and Position Estimation

International Journal of Distributed Sensor Networks, 2015
To solve the problems from the existing moving objects data models, such as modeling spatiotemporal object continuous action, multidimensional representation, and querying sophisticated spatiotemporal position, we firstly established an object-oriented ...
Qunyong Wu, Junyi Huang, Jianping Luo, Jianjun Yang   +3 more
doaj   +1 more source

Manitoba CPR Land Sales Spatial Data 2026

The Manitoba Canadian Pacific Railway (CPR) Land Sales Spatial Data contains records of agricultural land sales by the CPR to settlers in Manitoba from 1881 to 1927. The dataset includes the name of the purchaser, the legal description of the land (e.g.,
Spatial and Numeric Data Services, Archives and Special Collections   +1 more
core   +1 more source

Using balanced scorecard for evaluation of spatial data infrastructures : a case study in accordance with INSPIRE

, 2011
Spatial Data Infrastructures (SDIs) have been identified essential for environmental management and development activities around the world. Meanwhile, development of frameworks to monitor and evaluate SDIs is currently an important research area.
Ryden, Anders, Mansourian, Ali,, Harrie, Lars, Mansourian, Ali, Harrie, Lars,, Toomanian, Ara,, Toomanian, Ara, Lund University.   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Alberta CPR Land Sales Spatial Data 2026

The Alberta Canadian Pacific Railway (CPR) Land Sales Spatial Data contains records of agricultural land sales by the CPR to settlers in Alberta from 1883 to 1927.
Spatial and Numeric Data Services, Archives and Special Collections   +1 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

High-Resolution Daily Evapotranspiration Estimation in Arid Agricultural Regions Based on Remote Sensing via an Improved PT-JPL and CUWFM Fusion Framework

Remote Sensing
Evapotranspiration (ET) plays a crucial role in the terrestrial water cycle, especially in arid and semi-arid agricultural regions where precise water management is essential.
Hongwei Liu, Xiaoqin Wang, Hongyu Zhang, Mengmeng Li, Qunyong Wu   +4 more
doaj   +1 more source