Results 221 to 230 of about 4,369,639 (344)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

scMultiSim: simulation of single-cell multi-omics and spatial data guided by gene regulatory networks and cell-cell interactions. [PDF]

Nat Methods
Li H, Zhang Z, Squires M, Chen X, Zhang X.   +4 more
europepmc   +1 more source

Spatial Data Starter Kit for OnSSET Energy Planning in Kitui County, Kenya. [PDF]

Data Brief, 2022
Mwendwa DM, Tchouambe J, Hu E, Lanza MF, Brener AB, Hwang G, Khanfar L, Leonard A, Hirmer S, McCulloch M.   +9 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Towards a spatial data repository for archaeological research in the Romanian Mostiștea Basin and Danube Valley. [PDF]

Data Brief
Stal C, Covătaru C, De Wolf Q, Ignat T, Pecheniuk D, Lazăr C.   +5 more
europepmc   +1 more source

Multimedia Technology of Spatial Data Mining Based on Genetic Algorithm. [PDF]

Comput Intell Neurosci, 2022
Sun Y.
europepmc   +1 more source

Data supplement to "Aromatics and agriculture: A spatial approach to long-distance trade and the local economy of the Nabataeans"

, 2022
Eli J. S. Weaverdyck
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Novel pre-spatial data fusion deep learning approach for multimodal volumetric outcome prediction models in radiotherapy. [PDF]

Med Phys
Asbach JC, Singh AK, Iovoli AJ, Farrugia M, Le AH.   +4 more
europepmc   +1 more source

Including spatial data in nutrient balance modelling on dairy farms

, 2017
Maricke van Leeuwen, Corina van Middelaar, Cathelijne R. Stoof, J. Oenema, J.J. Stoorvogel, I.J.M. de Boer   +5 more
openalex   +1 more source