Results 211 to 220 of about 5,704,475 (316)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping. [PDF]

Nat Commun
Lusk D, Wolf S, Svidzinska D, Dormann CF, Kattge J, Bruelheide H, Sabatini FM, Damasceno G, Moreno Martínez Á, Violle C, Hending D, Hähn GJA, Tabeni S, Phartyal S, Gonçalves F, Kreft H, Schmidt M, Chen H, Güler B, Dolezal J, Pielech R, Guido A, Dwyer C, Napoleone F, Willie J, Gasper AL, Macía MJ, Chytry M, Lenoir J, Thakur D, Dengler J, Świerszcz S, Altman J, Mucina L, Nerlekar AN, Kakinuma K, Rawat P, Stančić Z, Testolin R, Hatim MZ, Rodrigues F, Homeier J, Marques MCM, McCarthy JK, El-Sheikh MA, Korznikov K, Gerberding K, Kattenborn T.   +47 more
europepmc   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Integrating single-cell RNA sequencing with spatial transcriptomics reveal the fibrosis-related genes in hepatocellular carcinoma. [PDF]

Front Immunol
Qiao W, Li L, Jin R, Hu C.
europepmc   +1 more source

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

Artificial Intelligence‐Assisted Workflow for Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling

Advanced Materials, EarlyView.
AI‐Assisted Workflow for (Scanning) Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling. Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of ...
Marc Botifoll, Ivan Pinto‐Huguet, Enzo Rotunno, Thomas Galvani, Catalina Coll, Payam Habibzadeh Kavkani, Maria Chiara Spadaro, Yann‐Michel Niquet, Martin Børstad Eriksen, Sara Martí‐Sánchez, Georgios Katsaros, Giordano Scappucci, Peter Krogstrup, Giovanni Isella, Andreu Cabot, Gonzalo Merino, Pablo Ordejón, Stephan Roche, Vincenzo Grillo, Jordi Arbiol   +19 more
wiley   +1 more source

CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization. [PDF]

Nucleic Acids Res
Feng X, Zheng J, Peng S, Jiang A, Ng KH, Lyu C, Jin Q, Chen L.   +7 more
europepmc   +1 more source

Physical Intelligence in Small‐Scale Robots and Machines

Advanced Materials, EarlyView.
“Physical intelligence” (PI) empowers biological organisms and artificial machines, especially at the small scales, to perceive, adapt, and even reshape their complex, dynamic, and unstructured operation environments. This review summarizes recent milestones and future directions of PI in small‐scale robots and machines.
Huyue Chen, Metin Sitti
wiley   +1 more source

A Submarine Landslides Database of Calabrian Continental Margins (Central Mediterranean Sea). [PDF]

Sci Data
Bianchini M, Chiocci FL, Ceramicola S.
europepmc   +1 more source

Operational spatial database

Design configuration and implementation of spatial database directly connected with the SAFEWAY ...
openaire   +1 more source