Results 311 to 320 of about 5,483,277 (408)

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

High-Resolution Geospatial Database: National Criteria-Air-Pollutant Concentrations in the Contiguous U.S., 2016-2020. [PDF]

Geosci Data J
Lu T, Kim SY, Marshall JD.
europepmc   +1 more source

Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This study optimizes sterilization methods for bioprinted 3D corneal stroma patches made from cornea‐derived decellularized extracellular matrix (Co‐dECM) hydrogels and human keratocytes. It demonstrates the superiority of electron beam sterilization in preserving the mechanical, biochemical, and immunomodulatory properties of hydrogels, ensuring ...
Jungbin Yoon, Yeon‐ju Lee, Minji Kim, Ju Young Park, Jinah Jang   +4 more
wiley   +1 more source

metsDB: a knowledgebase of cancer metastasis at bulk, single-cell and spatial levels. [PDF]

Nucleic Acids Res
Wu S, Zhang J, Wang Y, Qin X, Zhang Z, Lu Z, Kim P, Zhou X, Huang L.   +8 more
europepmc   +1 more source

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

Deep learning in single-cell and spatial transcriptomics data analysis: advances and challenges from a data science perspective. [PDF]

Brief Bioinform
Ge S, Sun S, Xu H, Cheng Q, Ren Z.
europepmc   +1 more source

Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario, Lorenzo Moroni, Carlos Mota   +2 more
wiley   +1 more source

Extracellular Matrix‐Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury

Advanced Healthcare Materials, EarlyView.
This study reports a novel strategy for preparing a biocompatible adhesive hydrogel crosslinked with a muscle tissue‐derived extracellular matrix (MEM) for in situ muscle regeneration. As a natural crosslinker, MEM not only mediates combinatorial polymer networks but also stimulates satellite cells to induce a cell‐free therapeutic solution.
Eun Je Jeon, Soohwan An, Seung Yeop Han, Eunseon Jeong, Young Seok Song, Jung Seung Lee, Seung‐Woo Cho   +6 more
wiley   +1 more source

Evidence for Cognitive Spatial Models from Ancient Roman Land-Measurement. [PDF]

Brain Sci
Riggsby AM.
europepmc   +1 more source

Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This research introduces DystroGel, a cutting‐edge biocompatible pathological hydrogel derived from decellularized dystrophic porcine heart tissue, suitable for tissue modeling applications. Rheological and proteomic analyses reveal structural and protein composition modifications, underscoring its unique properties.
Maila Chirivì, Fabio Maiullari, Marika Milan, Maria Grazia Ceraolo, Nicole Fratini, Alessandra Fasciani, Salma Bousselmi, Michael Stirm, Francesca Scalera, Francesca Gervaso, Michela Villa, Raffaello Viganò, Francesca Brambilla, Pierluigi Mauri, Elena De Falco, Dario Di Silvestre, Marco Costantini, Eckhard Wolf, Claudia Bearzi, Roberto Rizzi   +19 more
wiley   +1 more source