Results 51 to 60 of about 303 (236)

Between “Qui” and “Qua” and “Lì” and “Là”: Some Observations on Locative Adverbs and Linguistic Space in Italian

Quaderni di Linguistica e Studi Orientali
This article discusses some aspects of spatial conceptualisation in Italian, focusing on deixis and the Italian locative adverbs: the proximal qui and qua (‘here’), and the distal lì and là (‘there’).
Alice Giovanelli
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Spatial deixis in Lithuanian: demonstrative pronouns

Valoda nozīme un forma / Language Meaning and Form, 2017
This article deals with spatial deixis in Lithuanian (the issue of demonstratives). Spatial deixis is lexicalized by different parts of speech in different languages: by adverbs of place (e.g., here and there), verbs (come and go) and demonstratives. The demonstratives this and that are usually considered to be spatial deictics in their basic use.
openaire   +1 more source

Distribution of spatial demonstratives in Serbian literacy

Juznoslovenski filolog, 2022
In this paper we deal with the distribution of adverbial demonstratives in Serbian literacy, i.e. with their use in the literary and vernacular language. Considering the fact that the system of pronouns in the Serbian language has undergone certain changes, the aim of the paper is to determine whether these changes affected the pronominal ...
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Spatial Demonstratives and Physical Control [PDF]

Spatial demonstratives are deictic expressions used to point to a referent with language. In the standard view, they encode a spatial proximal\distal contrast between “near” (this) and “far” (that) from the speaker. Several studies have shown that such contrast maps on a perceptual contrast between peripersonal and extrapersonal space.
Angelo Mattia Gervasi, Anna Borghi, Francesco Mannella, Luca Tummolini   +3 more
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source