Results 121 to 130 of about 12,348,131 (312)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

The spatial effect of integrated economy on carbon emissions in the era of big data: a case study of China

open access: yesFrontiers in Ecology and Evolution
The digital economy has the characteristics of resource conservation, which can solve China’s high carbon emissions problems. The digital economy can quickly integrate with the real economy, forming an integrated economy.
Yan Wang, Qian Ke, Shuzhen Lei
doaj   +1 more source

The Production Effect Becomes Spatial

open access: yesExperimental Psychology
Abstract: In the verbal domain, it is well established that words read aloud are better remembered than their silently read counterparts. It has been hypothesized that this production effect stems from the addition of distinctive features, with the caveat that the processing that generates added features interferes with rehearsal.
Saint-Aubin, J.   +3 more
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Highly reactive, liquid diacrylamides via synergistic combination of spatially arranged curing moieties

open access: yesBeilstein Journal of Organic Chemistry, 2017
Six polymerizable N,N’-diacylamides containing spatially arranged N-acryl, N-allyl and/or N-alkyl groups were prepared via two-step syntheses and characterized by 1H/13C NMR-spectra, refractive index (RI) and viscosity measurements.
Maximilian Maier   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Spatial Modeling of the Impact of Human and Public Capital on Employment Convergence between Regions in Morocco: Time Period from 2010 to 2023.

open access: yesECONOMICS
This article explores spatial convergence in Morocco to assess whether the benefits of development are equitably distributed across regions, recognizing that growth in one region can influence its neighbors.
Marmad Toufik, Ritahi Oussama
doaj   +1 more source

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