Results 151 to 160 of about 12,348,131 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

China’s agricultural land transfer: carbon emissions driver or opportunity? The pivotal role of rural human capital revealed

Frontiers in Sustainable Food Systems
Research has found that the transfer of agricultural land in China has to some extent led to agricultural carbon emissions. Therefore, it is urgent to systematically analyze the reasons for carbon emissions caused by agricultural land transfer, find ways
Tianshu Quan, Hui Zhang, Tianli Quan, Yi Yu   +3 more
doaj   +1 more source

Spatial hydrological flow processes, water quality and vegetation community distributions in a natural floodplain fen

, 2016
We studied spatial patterns in inundation water quality in a floodplain fen in Poland, resulting from interacting hydrological flow processes. Using PCA and K-means cluster analysis, we identified four clearly distinguishable water types, related to ...
Schot, P.P., Spatial Ecology and Global Change, Okruszko, Tomasz, Keizer, F.M., Wassen, M.J., Environmental Sciences   +5 more
core   +1 more source

Spatial Science News from QUT:Industry Report,September 2006 [PDF]

, 2006
School Urban Development Stategic Planning; Spatial Science Student Awards with ...
Webb, Robert M.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The spatial effects of the household's food insecurity levels in Ethiopia: by ordinal geo-additive model

Frontiers in Nutrition
BackgroundFood insecurity and vulnerability in Ethiopia are historical problems due to natural- and human-made disasters, which affect a wide range of areas at a higher magnitude with adverse effects on the overall health of households.
Habtamu T. Wubetie, Habtamu T. Wubetie, Temesgen Zewotir, Aweke A. Mitku, Aweke A. Mitku, Zelalem G. Dessie, Zelalem G. Dessie   +6 more
doaj   +1 more source

Flood prone risk and amenity values: a spatial hedonic analysis [PDF]

This study examines the impact of flood hazard zone location on residential property values. The study utilises data from over 2,000 private residential property sales occurred during 2006 in North Shore City, New Zealand.
Samarasinghe, Oshadhi, Sharp, Basil M.H.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect of spatial location and SOA on visual selective attention

, 2004
The present study was intended to research the effect of spatial location and SOA on visual selective attention. Forty subjects involved in this experiments.
Y. N. Li, X. M. Zhang, T. Ran
core   +1 more source