Results 221 to 230 of about 2,853,438 (289)

Potential for use of Al/machine learning for pharmacovigilance: Is there a role for regulators?

British Journal of Clinical Pharmacology, EarlyView.
Christina Gao, Ashley M. Hopkins, Andrew Rowland, Stephen Bacchi   +3 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Combining molecular transmission network analysis and spatial epidemiology to reveal HIV-1 transmission pattern among the older people in Nanjing, China. [PDF]

Virol J
Xu Y, Jiang T, Jiang L, Shi H, Li X, Qiao M, Wu S, Wu R, Yuan X, Wang J, Zhu Z.   +10 more
europepmc   +1 more source

Copula‐based joint modelling of emergency department visits with time‐varying dependence

Canadian Journal of Statistics, EarlyView.
Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley   +1 more source

Joint copula‐based beta regression with covariate‐dependent dispersion for malaria indicators

Canadian Journal of Statistics, EarlyView.
Abstract Malaria surveillance relies on multiple indicators that reflect different aspects of transmission and disease burden, yet these outcomes are often analyzed separately under constant‐variance assumptions. Such approaches may obscure residual dependence and heterogeneity in variability. Using Demographic and Health Survey data from Burkina Faso (
Guanjie Lyu, Cindy Feng
wiley   +1 more source

Z‐residuals diagnostics for Cox models: Functional‐form misspecification versus nonproportional hazards

Canadian Journal of Statistics, EarlyView.
Abstract Primary biliary cholangitis (PBC) is a progressive autoimmune cholestatic disease for which modelling death, with transplantation as a competing event, is clinically important. Cox proportional hazards (PH) models are widely used, but standard diagnostics detect lack of fit without distinguishing non‐PH from misspecified covariate functions ...
Tingxuan Wu, Cindy Feng, Longhai Li
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU‐Funded Projects

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world data are increasingly important for regulatory and health technology assessment decision‐making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe projects in the MetReal cluster, this review summarizes common barriers and ...
Martin Russek, Jonas Peltner, Kerstin Pfeifer, Theodoros N. Arvanitis, Dirk De Valck, Sieta T. de Vries, Michel Dumontier, Vera Ehrenstein, Omaima El Hakouni, Gregory Epiphaniou, Gokhan Ertaylan, Joana Fernandes, Scott Hansen, Stuart Harrison, Erzsébet Horváth‐Puhó, Saif Ul Islam, Pekka Kahri, Julia K. Mader, Carsten Maple, Nikolaos Matragkas, Shivani Misra, Peter G.M. Mol, Anne Paakinaho, Sami Pakarinen, Martina Radanović, Evy Reviers, Kathrine Kold Sørensen, Marco Spruit, Christina Tikka, Anna‐Maija Tolppanen, Christian Torp‐Pedersen, Mirna Vela, Thuan Vo, Puriya Daniel Würtz Yazdanfard, Britta Haenisch   +34 more
wiley   +1 more source

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Climate‐Related Risk Factors and Banks' Operational Risk: The Case of Italian Significant Institutions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper investigates significant Italian banks' exposure to climate‐related physical risks from the perspective of operational risk. Focusing on acute physical risks, proxied by floods and storms, the analysis adopts a microeconomic and spatial perspective to assess how the territorial distribution of banks' branches at the provincial ...
Maria Debora Braga, Dario Musolino, Gianmarco Vacca   +2 more
wiley   +1 more source