Results 141 to 150 of about 3,984,310 (349)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Empirical evaluations between beta-diversity, environmental heterogeneity, and spatial extent among multiple taxonomic groups [PDF]

Acta Limnologica Brasiliensia
Aim Beta diversity is expected to increase due to environmental heterogeneity and spatial extent. However, it remains unknown whether the response of beta diversity to these variables is consistent among different taxonomic groups. I investigated whether
Carlos Henrique Lopes Liborio
doaj   +1 more source

Spatial Heterogeneity and the Wage Curve Revisited [PDF]

Most ‘wage curve’ studies treat local labour markets as independent ‘islands’ in the national economy. However, when a local labour market is in close proximity of other labour markets, a local shock that increases unemployment may not lead to lower pay ...
Jacques Poot, Peter Nijkamp, Simonetta Longhi   +2 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

MODELING SPATIAL DEPENDENCE AND SPATIAL HETEROGENEITY IN COUNTY YIELD FORECASTING MODELS [PDF]

The implications of ignoring potential spatial dependence in county-level yield data are discussed. Spatial dependence in a county-level yield data set is identified and methods for correcting the dependence via spatial weighting matrices and generalized
DiRienzo, Cassandra, Fackler, Paul L., Goodwin, Barry K.   +2 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Resolving spatial response heterogeneity in glioblastoma

European Journal of Nuclear Medicine and Molecular Imaging
Abstract Purpose Spatial intratumoral heterogeneity poses a significant challenge for accurate response assessment in glioblastoma. Multimodal imaging coupled with advanced image analysis has the potential to unravel this response heterogeneity.
Julian Ziegenfeuter, Claire Delbridge, Denise Bernhardt, Jens Gempt, Friederike Schmidt-Graf, Dennis Hedderich, Michael Griessmair, Marie Thomas, Hanno S Meyer, Claus Zimmer, Bernhard Meyer, Stephanie E Combs, Igor Yakushev, Marie-Christin Metz, Benedikt Wiestler   +14 more
openaire   +4 more sources

The role of space in urban housing market [PDF]

This presentation emphasizes the quantitative analysis of space in relation to hedonic housing price models. Three aspects of space will be highlighted: i) spatial heterogeneity (spatial patterns): hedonic housing amenities may be valued differently in ...
Arnab Bhattacharjee, Eduardo Castro, Joao Marques   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Spatial Heterogeneity of Willingness to Pay for Forest Management

, 2017
The paper investigates the spatial heterogeneity of public’s preferences for the implementation of a new country-wide forest management and protection program in Poland. Spatial econometric methods and high resolution geographical information system data
M. Czajkowski, Wiktor Budziński, D. Campbell, Marek Giergiczny, N. Hanley   +4 more
semanticscholar   +1 more source