Results 121 to 130 of about 422,181 (302)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Sail: A spatial index library for efficient application integration
, 2005 With the proliferation of spatial and spatio-temporal data that are produced everyday by a wide range of applications, Geographic Information Systems (GIS) have to cope with millions of objects with diverse spatial characteristics.
Marios Hadjieleftheriou +2 more
core
Research of Hybrid Spatial Index Technology in 3DGIS
Gong-kuang zidonghua, 2010 In view of bad performance of single index technology in 3D space, advantages and disadvantages of octree and classic R-tree were analyzed. A hybrid index technology combining octree and R-tree was proposed which was named ORSI.
WANG Ji-shui, GU Wei-jie
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
GP VERSUS GLS SPATIAL INDEX MODELS TO FORECAST SINGLE-FAMILY HOME PRICES
This paper investigates use of genetic programming regression models to forecast home values. Neighborhood prices in a city are represented by a quarterly index.
MAK KABOUDAN
core
Frontiers in Plant ScienceStand spatial structure and sapling diversity are essential for maintaining ecosystem stability. However, the dynamic characteristics of stand spatial structure, its driving factors, and its influence on sapling diversity remain unclear.
Lingyan Li +21 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source