Results 101 to 110 of about 10,275,262 (317)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Pengaruh Interaksi Spasial Antara Kota Surakarta dengan Kawasan Perkotaan Sekitarnya Terhadap Pertumbuhan Perkotaan

Jurnal Pembangunan Wilayah dan Kota, 2020
Cities in the systems perspective of cities are related and interconnected with each other. So is in the Subosukawonosraten region which is an Ex-residency region of Surakarta.
Muhammad Iqbal Sugestiadi, Yudi Basuki
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Interactive design of new media images and architectural space: taking Hangzhou as an example

Journal of Asian Architecture and Building Engineering
Traditional architectural space design often relies on fixed display boards, paper guides, and static displays. Viewers can only passively receive information and lack opportunities to interact with the displayed content, making it difficult to generate ...
Yutuo Fei
doaj   +1 more source

A primer for working with the Spatial Interaction modeling (SpInt) module in the python spatial analysis library (PySAL)

, 2016
This primer provides a practical guide to get started with spatial interaction modeling using the SpInt module in the python spatial analysis library (PySAL).
Taylor M. Oshan
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Interaksi Spasial Perekonomian dan Ketenagakerjaan Antar Kabupaten/Kota di Provinsi Jambi [PDF]

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2014
An analysis of the regional development needs to take into account the problems within regions (intraregional) and the balance of development between regions (interregional).
Yanti Heryanti, Junaidi, Yulmardi
doaj  

Multilevel Modelling with Spatial Interaction Effects with Application to an Emerging Land Market in Beijing, China

PLoS ONE, 2015
This paper develops a methodology for extending multilevel modelling to incorporate spatial interaction effects. The motivation is that classic multilevel models are not specifically spatial.
Guanpeng Dong, Richard J. Harris, K. Jones, Jianhui Yu   +3 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source