Results 121 to 130 of about 10,275,262 (317)

Commuting and Panel Spatial Interaction Models: Evidence of Variation of the Distance-Effect over Time and Space [PDF]

We apply spatial interaction models using panel data to explain commuting behaviour in the Netherlands. Our main conclusion is that the distance-decay effect is not constant over time and that changes in this effect are region specific.
Jos Van Ommeren, Wouter Vermeulen
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Une approche prospective de la configuration des disparités économiques régionales au sein de l'Union européenne par la modélisation et la simulation

Cybergeo, 2011
The aim of this article is to replace the question of the last two enlargements in the debate on the future of the cohesion policy. The interest is to estimate the process of the spatial expression of the convergence and the regional growth in the EU ...
Sébastien Bourdin, Patrice Langlois, Bernard Elissalde, Dominique Goyat   +3 more
doaj   +1 more source

The Identification of Industrial Clusters – Methodical Aspects in a Multidimensional Framework for Cluster Identification [PDF]

We use a combination of measures of spatial concentration, qualitative input-output analysis and innovation interaction matrices to identify the horizontal and vertical dimension of industrial clusters in Saxony in 2005.
Alexander Kubis, Matthias Brachert, Mirko Titze   +2 more
core  

Correlated hopping of electrons: Effect on the Brinkman-Rice transition and the stability of metallic ferromagnetism

, 2001
We study the Hubbard model with bond-charge interaction (`correlated hopping') in terms of the Gutzwiller wave function. We show how to express the Gutzwiller expectation value of the bond-charge interaction in terms of the correlated momentum-space ...
A. Georges, A. Schiller, D. Vollhardt, D. Vollhardt, D. Vollhardt, D.K. Campbell, F. Gebhard, F. Gebhard, J. Amadon, J. Hubbard, J. Kanamori, J. Schlipf, J. Wahle, J.E. Hirsch, J.E. Hirsch, J.E. Hirsch, J.T. Gammel, M. Kollar, M. Ulmke, M.C. Gutzwiller, M.C. Gutzwiller, M.C. Gutzwiller, P. Fazekas, S. Tang, W. Metzner, W. Metzner, W. Metzner, W. Metzner, W.F. Brinkman   +28 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Traffic–Tourism Spatial Interaction of Lai-Qu Expressway Based on the Traffic Flow Data

Land
In the Taihang Mountain Tourism Development Plan (2020–2035), the Taihang Mountain Expressway is included in the construction of the National Tourism Scenic Road around Taihang Mountain to promote the integrated development of regional transportation and
Yujian Gao, Long Bai, Shengqiang Liu, Hongjuan Zheng, Jie Liu, Jinxiang Cheng, Haiyuan Yao, Qing Zhao   +7 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Connectionist Model of Spatial Knowledge Acquisition in a Virtual Environment [PDF]

, 2003
This paper proposes the use of neural networks as a tool for studying navigation within virtual worlds. Results indicate that network learned to predict the next step for a given trajectory, acquiring also basic spatial knowledge in terms of landmarks ...
O'Hare, G.M.P., Reilly, R., Sas, Corina
core