Results 71 to 80 of about 10,275,262 (317)

Spatial Complex Network Analysis and Accessibility Indicators: the Case of Municipal Commuting in Sardinia, Italy [PDF]

, 2011
In this paper a contribution is presented with respect to accessibility indicators modelling for commuters moving through the municipalities of Sardinia, in Italy.
Caschili, Simone, Chessa, Alessandro, De Montis, Andrea   +2 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interaksi Spasial Kondisi Sosial-Ekonomi Terhadap Kerawanan Kejahatan Di Kota Bandung (Studi Kasus Sumur Bandung)

Jambura Geoscience Review, 2019
Crime is an unplanned change due to the process of urban development. The geographical approach is able to analyze spatial interactions of criminogenic factors into crime phenomenon.
Moh. Dede, Dede Sugandi, Iwan Setiawan
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Complementarity in the Central Area of Mexico: The Spatial Interaction between Economic Activity and Connectivity [PDF]

Prostranstvennaâ Èkonomika
Road connectivity is essential for regional development, which stems from the complementarity and economic diversification of Mexico’s regions. Upgraded road infrastructure boosts access to markets, resources, and services, improving population mobility ...
Claudia Tello, Amilcar Morales, Mario Ledesma   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Impact of spatial organization on a novel auxotrophic interaction among soil microbes [PDF]

, 2018
A key prerequisite to achieve a deeper understanding of microbial communities and to engineer synthetic ones is to identify the individual metabolic interactions among key species and how these interactions are affected by different environmental factors.
Asally, Munehiro, Eichmann, Ruth, Jiang, Xue, Schäfer, Patrick, Soyer, Orkun S., Zerfaß, Christian   +5 more
core   +1 more source

A new way of determining distance decay parameters in spatial interaction models with application to job accessibility analysis in Sweden

European Journal of Transport and Infrastructure Research, 2016
In this paper we explore and compare various techniques for the calculation of distance decay parameters which are estimated using statistical methods with half-life decay parameters which are derived mathematically. Half-life models appear to be a valid
John Östh, J. Lyhagen, A. Reggiani
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Spatial pricing strategies in Italy’s urban gasoline markets: evidence from medium-sized cities using a spatial econometric framework

Regional Studies, Regional Science
Additional evidence is essential to determine the extent and manner in which spatial variables influence the variation in gasoline prices across cities. In particular, we focus on two major Italian cities: Milan and Naples, which are the second and third
Angela Stefania Bergantino, Giulio Fusco, Mario Intini   +2 more
doaj   +1 more source