Results 41 to 50 of about 481,845 (319)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Spatial variation in size at onset of maturity of female southern rock lobster Jasus edwardsii around Tasmania, Australia

Scientia Marina, 2006
P align=justify>The size at onset of maturity (SOM) of female Jasus edwardsii (Hutton, 1875) was estimated at 50 sites around Tasmania, Australia, based on the presence of ovigerous setae.
Caleb Gardner, Stewart Frusher, Neville Barrett, Malcolm Haddon, Colin Buxton   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Poznań School of Socio-Economic Geography (And Spatial Management) of Adam Mickiewicz University (In Poznań)

Quaestiones Geographicae, 2019
This article presents the general characteristics of the Poznań school of socio-economic geography (and spatial management). Scientific school is usually understood as a community of scholars, representatives of a given scientific discipline, associated ...
Parysek Jerzy J.
doaj   +1 more source

Rural Areas as the Origin and Destination of Permanent Internal Migrations between 2002 and 2017 in Poland. A Local-Level Analysis (Nuts 5)

Quaestiones Geographicae, 2020
The main aim of the study is to identify the main streams of permanent migration and determine their reach. Special attention has been paid to rural areas (a rural commune, the rural area of an urban–rural commune) as the origin and destination of ...
Ilnicki Dariusz
doaj   +1 more source

Spatial Data Management

, 2011
Spatial database management deals with the storage, indexing, and querying of data with spatial features, such as location and geometric extent. Many applications require the efficient management of spatial data, including Geographic Information Systems,
Nikos Mamoulis, Mamoulis, Nikos, Mamoulis, N   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Visual Database System for Spatial and Non-spatial Data Management [PDF]

, 1998
A symbolic image is an array representing a set of objects and a set of direction relations among them. Symbolic images can be the source for retrieving direction relations via the Pictorial Query-by-Example (PQBE) language, a visual language which generalises from the example given by the user and is based on skeleton images which are by themselves ...
Theodore Dalamagas 0001, Timos K. Sellis, L. Sinos   +2 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source