Results 71 to 80 of about 1,675,665 (284)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Planning and practice of the Polish-Czech transborder road network development: From ineffective top-down plans to bottom-up lack of coordination?

European Spatial Research and Policy
In this article, the authors analyse the development policy of the major road network in the Polish-Czech border areas in 1958–2024. The methodology of content analysis covering histori­cal bilateral and European planning documents and GIS spatial ...
Marek Furmankiewicz, Krzysztof Buryło, Ivo Dostál, Maria Hełdak, Joanna Lipsa, Maciej Zathey   +5 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Dimensionality of an urban transport system based on ISO 37120 indicators for the case of selected European cities

Engineering Management in Production and Services, 2019
The study aims to assess transport systems in terms of ISO 37120 indicators in selected European cities. Using the principal components analysis, the research identified significantly correlated variables associated with urban transport.
Hajduk Sławomira, Litavniece Lienite
doaj   +1 more source

Identification of a Soft Coral Garden Candidate Vulnerable Marine Ecosystem (VME) Using Video Imagery, Davis Strait, West Greenland

Frontiers in Marine Science, 2020
The term vulnerable marine ecosystem (VME) was introduced to facilitate the spatial management of deep-seas, identifying those habitats vulnerable to anthropogenic disturbance, such as trawling.
Stephen Long, Stephen Long, Bridget Sparrow-Scinocca, Martin E. Blicher, Nanette Hammeken Arboe, Mona Fuhrmann, Kirsty M. Kemp, Rasmus Nygaard, Karl Zinglersen, Chris Yesson   +9 more
doaj   +1 more source

THE INFLUENCE OF SPATIAL LAND USE PATTERNS ON RURAL AMENITY VALUES AND WILLINGNESS TO PAY FOR GROWTH MANAGEMENT: EVIDENCE FROM A CONTINGENT CHOICE SURVEY [PDF]

This paper reports on a contingent choice study in which residents of a rural Rhode Island community were asked to express their preferences for packages of growth management outcomes, where surveys presented both spatial and non-spatial attributes of ...
Bauer, Dana Marie, Johnston, Robert J., Swallow, Stephen K.   +2 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Holistic Approach to Fishery Management: Evidence and Insights from a Central Mediterranean Case Study (Western Ionian Sea)

Frontiers in Marine Science, 2017
The new Common Fisheries Policy (CFP) is designed to represent an appropriate response to the uncertainties and challenges facing the fisheries sector.
Tommaso Russo, Tommaso Russo, Isabella Bitetto, Pierluigi Carbonara, Roberto Carlucci, Lorenzo D'Andrea, Lorenzo D'Andrea, Maria T. Facchini, Giuseppe Lembo, Porzia Maiorano, Letizia Sion, Maria T. Spedicato, Angelo Tursi, Stefano Cataudella   +13 more
doaj   +1 more source

Smart City Model and Urban Spatial Management

Gospodarka Narodowa. The Polish Journal of Economics, 2020
The smart city concept, implemented in many cities around the world, has captured the attention of theoreticians and practitioners. It has spawned various models related to service innovations, urban maturity and social participation.
Sławomira Hajduk
doaj   +1 more source