Results 121 to 130 of about 7,177,543 (330)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Performance analysis of cooperative wireless sensor network with index-based modulation

The Journal of Engineering, 2019
Spatial modulation (SM) emerges as a potential technique for next generation wireless networks. Enhanced spectral efficiency and equitable system complexity led SM to various innovations.
Subhashini Neelamegam, Murugan Mahalingam   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effects of motor preparation and spatial attention on corticospinal excitability in a delayed-response paradigm [PDF]

, 2007
The preparation of motor responses during the delay period of an instructed delay task is associated with sustained neural firing in the primate premotor cortex.
Mars, R.B., John C. Rothwell, Sven Bestmann, Patrick Haggard, Bestmann, S., Rothwell, J.C., Haggard, P., Rogier B. Mars   +7 more
core   +1 more source

Effects of Channel Estimation on Spatial Modulation

In this letter, we investigate the effects of training-based channel estimation on the achievable performance of the recent spatial modulation (SM) based multiple-input multiple-output (MIMO) scheme.
Sugiura, Shinya, Hanzo, Lajos
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Spatial structure of contextual modulation

Journal of Vision, 2013
Contextual effects are ubiquitous in vision and provide a means for detectors with localized receptive fields to encode global properties of a stimulus. Although the nature of the neural connections is complex, the majority of evidence supports the Gestalt idea of collinearity; interactions are greatest when the target and surround orientations are ...
I, Mareschal, C W G, Clifford
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Modulation of coherence and polarization using liquid crystal spatial light modulators [PDF]

, 2009
We propose a method for modulation of coherence and polarization of electromagnetic fields, employing two crossed zero-twisted nematic liquid crystal spatial light modulators. In contrast to a similar technique analyzed by Shirai and Wolf [J. Opt.
VICTOR MANUEL ARRIZON PEÑA, GABRIEL CONSTANTINO MARTINEZ NICONOFF   +1 more
core  

Performance of BPSK subcarrier intensity modulation free-space optical communications using a log-normal atmospheric turbulence model [PDF]

, 2010
In this paper, we present simulation results for the bit error rate (BER) performance and the fading penalty of a BPSK - subcarrier intensity modulation (BPSK-SIM) free-space optical (FSO) communication link in a log-normal atmospheric turbulence model ...
S. S. Muhammad, Z. Ghassemlooy, E. Leitgeb, Tang, Xuan, Muhammad, Sajid Sheikh, S. Rajbhandari, Ghassemlooy, Zabih, Popoola, Wasiu Oyewole, W. O. Popoola, Kandus, Gorazd, Leitgeb, Erich, Rajbhandari, Sujan, X. Tang, G. Kandus   +13 more
core   +1 more source