Results 41 to 50 of about 292,599 (242)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Spatial organization to facilitate action

PLOS ONE, 2019
Humans exert a great deal of control over our local environments-selecting and arranging the many objects around us on the basis of conflicting task-demands, aesthetic preferences, and habitual convenience. Because routine behaviour necessitates that we regularly find and access these objects, the particular arrangements we choose can influence the ...
Grayden J. F. Solman, Alan Kingstone
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Integration of Local Resources in Search of a New Product – on the Example of the Lublin Region (Poland)

European Countryside, 2022
Regional development is very much conditioned by the quality and quantity of internal resources, as well as the level of use that is or can be made of these. Local resources are often features, factors and phenomena in a defined territory that are unique
Bański Jerzy
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Different Faces of Participation: Social Involvement in Rural Planning in Poland

Quaestiones Geographicae
The article deals with public participation in two dimensions of local rural planning: development and spatial planning. The research consisted in determining, with the help of constructed indexes, the level of participation of rural residents in various
BEDNAREK-SZCZEPAŃSKA MARIA, MAZUREK DAMIAN   +1 more
doaj   +1 more source

Neighbouring the different: Social interaction in a Warsaw subarea

Bulletin of Geography. Socio-Economic Series, 2018
In the paper patterns of social interaction are examined, as shaped by an inflow of new residents to an inner-city subarea characterized by a low socio-economic status and featuring ethnic homogeneity. The empirical material is derived from a set of semi-
Korcelli-Olejniczak Ewa, Piotrowski Filip   +1 more
doaj   +1 more source

Hippocampal Representational Organization and Spatial Context [PDF]

Hippocampus, 1999
The hippocampus appears to undergo continual representational reorganization as animals navigate their environments. This reorganization is postulated to be reflected spatially in terms of changes in the ensemble of place cells activated, as well as changes in place field specificity and reliability for cells recorded in both hilar/CA3 and CA1 regions.
S J, Mizumori, K E, Ragozzino, B G, Cooper, S, Leutgeb   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source