Results 151 to 160 of about 7,586,338 (346)

Policies to Address Spatial Mismatch

open access: yes, 2012
Spatial mismatch between workers and jobs is of policy concern for two reasons. First, labour surpluses in some locations contribute to labour market disadvantage. Second, other locations may experience labour shortages which restrict economic growth. Spatial mismatch usually refers to mismatches within metropolitan areas in developed countries.
openaire   +2 more sources

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

open access: yesAdvanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang   +10 more
wiley   +1 more source

Adverse Selection, Segmented Markets, and the Role of Monetary Policy [PDF]

open access: yes
A model is constructed in which trading partners are asymmetrically informed about future trading opportunities and where spatial and informational frictions limit arbitrage between markets.
Sanches, Daniel, Williamson, Stephen
core   +1 more source

Policy spillovers in a regional target-setting regime [PDF]

open access: yes, 2004
The present UK government has introduced a decentralised, target-driven framework for the delivery of regional policy in England. This paper analyses the operation of such a regime when there are spatial spillovers about which the government is ...
Learmonth, David, Swales, J. Kim
core   +2 more sources

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

open access: yesAdvanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu   +8 more
wiley   +1 more source

DETERMINANTS OF INVESTME??T FLOWS IN U.S. MANUFACTURING [PDF]

open access: yes
The purpose of the paper is to test the long-run steady state of growth factors hypothesized to influence U.S. manufacturing investment flows. These factors include agglomeration, market structure, labor, infrastructure, and fiscal policy.
Jason P. Brown   +2 more
core  

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

open access: yesAdvanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim   +10 more
wiley   +1 more source

The ‘Trade-off’ between Spatial Equity and Economic Efficiency Revisited: Evidence from the US States [PDF]

open access: yes
The principle aims of regional policy can be encapsulated in terms of ‘spatial equity’ and ‘economic efficiency’. Establishing the relation between these two aims is of fundamental importance.
Alexiadis, Stilianos   +1 more
core   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

open access: yesAdvanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao   +14 more
wiley   +1 more source

Economic Performace in Rural England [PDF]

open access: yes
English economic policy requires different levels of government to pursue incommensurate, urban-centric, objectives. Rural areas are characterised by ‘softer’ development approaches centring on relocalisation.
Don Webber, Nigel Curry
core  

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