Results 71 to 80 of about 1,186,895 (272)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Grand Challenge: Real-time Destination and ETA Prediction for Maritime Traffic

, 2018
In this paper, we present our approach for solving the DEBS Grand Challenge 2018. The challenge asks to provide a prediction for (i) a destination and the (ii) arrival time of ships in a streaming-fashion using Geo-spatial data in the maritime context ...
Bodunov, Oleh, Brito, Andrey, Fetzer, Christof, Martin, André, Schmidt, Florian   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of Remote Sensing and GIS for spatial prediction of vector-borne diseases transmission: A systematic review [PDF]

Journal of Vector Borne Diseases, 2012
There have been several attemps made to the appreciation of remote sensing and GIS for the study of vectors,biodiversity, vector presence, vector abundance and the vector-borne diseases with respect to space and time.This study was made for reviewing and
M. Palaniyandi
doaj  

Unsupervised Emergence of Egocentric Spatial Structure from Sensorimotor Prediction [PDF]

, 2019
Despite its omnipresence in robotics application, the nature of spatial knowledgeand the mechanisms that underlie its emergence in autonomous agents are stillpoorly understood. Recent theoretical works suggest that the Euclidean structure ofspace induces
Garcia Ortiz, M., Laflaquiere, A.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A geostatistical model based on Brownian motion to Krige regions in R2 with irregular boundaries and holes [PDF]

, 2019
Master's Project (M.S.) University of Alaska Fairbanks, 2019Kriging is a geostatistical interpolation method that produces predictions and prediction intervals.
Bernard, Jordy
core  

When and Where: Predicting Human Movements Based on Social Spatial-Temporal Events

, 2014
Predicting both the time and the location of human movements is valuable but challenging for a variety of applications. To address this problem, we propose an approach considering both the periodicity and the sociality of human movements. We first define
Kong, Xiangnan, Wang, Fengjiao, Yang, Ning, Yu, Philip S.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source