Results 71 to 80 of about 607,674 (294)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Efficient Pansharpening by Joint-Modality Recursive Training
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingMultispectral images captured by remote sensing systems usually have low spatial resolution. Pansharpening offers a promising solution by enhancing the resolution of these low-resolution multispectral images to a high-resolution multispectral without the
Qilei Li +5 more
doaj +1 more source
Технічна інженерія, 2019 The mathematical expressions, specifying the estimation of the capabilities of remote sensing satellites with opto-electronic imaging equipment for observing the Earth’s surface with the necessary (predetermined) spatial resolution of the ...
I.A. Bespalko +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
An Optimized YOLOv11 Framework for the Efficient Multi-Category Defect Detection of Concrete Surface
SensorsThoroughly and accurately identifying various defects on concrete surfaces is crucial to ensure structural safety and prolong service life. However, in actual engineering inspections, the varying shapes and complexities of concrete structural defects ...
Zhuang Tian +5 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Remote Sensing, 2019 As an important land-surface parameter, vegetation phenology has been estimated from observations by various satellite-borne sensors with substantially different spatial resolutions, ranging from tens of meters to several kilometers. The inconsistency of
Licong Liu +5 more
doaj +1 more source