Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Ultra-High Spatial Resolution Clinical Positron Emission Tomography (PET) Systems
Applied SciencesPositron emission tomography (PET) is an imaging modality for non-invasive visualization and quantification of molecular pathways in human diseases, with applications spanning clinical practice and biomedical research.
Myungheon Chin +3 more
doaj +1 more source
Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain [PDF]
, 2011 Peifang Tian +4 more
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Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
High-Spatial-Resolution OFDR Distributed Temperature Sensor Based on Step-by-Step and Image Wavelet Denoising Methods [PDF]
, 2022 Cailing Fu +6 more
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Perceptual Complexity as Normalized Shannon Entropy
EntropyComplexity is one of the most important variables in how the brain performs decision making based on esthetic values. Multiple definitions of perceptual complexity have been proposed, with one of the most fruitful being the Normalized Shannon Entropy one.
Norberto M. Grzywacz
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FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
A Review of Enhancement Techniques for Cone Beam Computed Tomography Images
NTU Journal of Engineering and TechnologyCone Beam Computed Tomography (CBCT) has emerged as a valuable imaging modality for various medical applications due to its ability to provide three-dimensional information with minimal radiation exposure. However, CBCT images often suffer from inherent
Hassn Mazin Al-alaaf +1 more
doaj +1 more source
Twenty-four-micrometer-pitch microelectrode array with 6912-channel readout at 12 kHz via highly scalable implementation for high-spatial-resolution mapping of action potentials [PDF]
, 2017 Jun Ogi +10 more
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